Prochlorperazine-GA

מדינה: אוסטרליה

שפה: אנגלית

מקור: Department of Health (Therapeutic Goods Administration)

מרכיב פעיל:

Prochlorperazine maleate

זמין מ:

Actavis Pty Ltd

סיווג:

Medicine Registered

עלון מידע

_ _
PROCHLORPERAZINE-GA

Prochlorperazine maleate_ _
_CONSUMER MEDICINE INFORMATION _

WHAT IS IN THIS LEAFLET 

This leaflet answers some 
common questions about 
Prochlorperazine-GA. 

It does not contain all the 
available information. 

It does not take the place of 
talking to your doctor or 
pharmacist. 

All medicines have risks and 
benefits. Your doctor has weighed 
the risks of you taking 
Prochlorperazine-GA against the 
benefits they expect it will have for 
you. 

IF YOU HAVE ANY CONCERNS ABOUT 
TAKING THIS MEDICINE, ASK YOUR 
DOCTOR OR PHARMACIST. 

KEEP THIS LEAFLET WITH THE 
MEDICINE. You may need to read 
it again. 

WHAT PROCHLORPERAZINE-GA 
IS USED FOR 

Prochlorperazine-GA belongs to a 
group of medicines called 
phenothiazines. It helps to correct 
chemical imbalances in the brain, 
allowing it to function correctly. 
These chemicals may also affect 
the parts of the brain which control 
nausea (feeling sick) and 
vomiting. 

Prochlorperazine-GA is used to 
treat nausea, vomiting and 
dizziness due to various causes, 
including migraine (severe 
headache). 

Your doctor may have prescribed 
Prochlorperazine-GA for another 
reason. 

ASK YOUR DOCTOR IF YOU HAVE ANY 
QUESTIONS ABOUT WHY 
PROCHLORPERAZINE-GA HAS BEEN 
PRESCRIBED FOR YOU. 

This medicine is available only 
with a doctor’s prescription. 

Prochlorperazine-GA is not 
recommended for use in children 
(under the age of 2 years or 
children under 10 kg in weight) 

BEFORE YOU TAKE 
PROCHLORPERAZINE-GA  

_WHEN YOU MUST NOT TAKE IT _
_ _
DO NOT TAKE PROCHLORPERAZINE-
GA IF YOU HAVE AN ALLERGY TO: 
• Prochlorperazine 
•  The group of medicines called 
phenothiazines 
•  Any of the ingredients listed at 
the end of this leaflet 
Symptoms of an allergic reaction 
to Prochlorperazine-GA may 
include: 
•  Shortness of breath, 
wheezing or difficulty in 
breathing 
•  Swe

מאפייני מוצר

PROCHLORPERAZINE-GA  
_PRODUCT INFORMATION _

Prochlorperazine-GA PI v2 100712 
Page 1 of 8 

NAME OF THE MEDICINE

PROPRIETARY NAME: 

PROCHLORPERAZINE-GA 5MG TABLETS 
NON-PROPRIETARY NAME: 
Prochlorperazine maleate 
CHEMICAL NAME: 
2 chloro-10-(3-(4-methyl piperazinyl)-propyl) phenothiazine 
MOLECULAR WEIGHT: 

606.2 
MOLECULAR FORMULA: 
C
20
H
24
CIN
3
S.2C
4
H
4
O
4

CAS NUMBER:
 84-02-6 
STRUCTURE: 

DESCRIPTION

Prochlorperazine maleate contains 62% of the active base
prochlorperazine. It is an 
odourless, nonhydroscopic, white or almost white, fine granular
powder, which becomes 
coloured on exposure to light. It is sparingly soluble (about 0.1%)
in water, ethanol or 
methanol and is insoluble in ether or chloroform. 

Prochlorperazine tablets contain 5mg of prochlorperazine maleate. The
tablets also contain 
the following excipients: lactose, maize starch, purified water,
colloidal anhydrous silica and 
magnesium stearate. 

PHARMACOLOGY 

Prochlorperazine is a phenothiazine with a piperazine moiety in the
side chain. It possesses 
strong antiemetic and antipsychotic activity with less sedative
action than chlorpromazine. 

PHARMACODYNAMICS 
As with other phenothiazines, prochlorperazine has actions on several
neurotransmitter 
systems: 
1.  Antidopamine action, which probably contributes to both the
therapeutic effect and 
unwanted effects including extrapyramidal disorders and endocrine
disturbances. 
2.  α-Adrenoreceptor antagonism, which contributes to
cardiovascular side effects such 
as orthostatic hypotension and reflex tachycardia. 
3.  Potentiation of noradrenaline by blocking its reuptake into
nerve terminals. 
4.  Weak anticholinergic action. 
5.  Weak antihistamine action. 
6.  Weak serotonin antagonism. 

Prochlorperazine also has an effect on temperature control
and blocks conditioned 
avoidance responses. 
PROCHLORPERAZINE-GA  
_PRODUCT INFORMATION _

Prochlorperaz