PHENOBARBITAL tablet

מדינה: ארצות הברית

שפה: אנגלית

מקור: NLM (National Library of Medicine)

מרכיב פעיל:

PHENOBARBITAL (UNII: YQE403BP4D) (PHENOBARBITAL - UNII:YQE403BP4D)

זמין מ:

Cardinal Health

INN (שם בינלאומי):

PHENOBARBITAL

הרכב:

PHENOBARBITAL 16.2 mg

סוג מרשם:

PRESCRIPTION DRUG

מצב אישור:

unapproved drug other

מאפייני מוצר

PHENOBARBITAL- PHENOBARBITAL TABLET
CARDINAL HEALTH
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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PHENOBARBITAL TABLETS, USP
CIV
RX ONLY
WARNING: MAY BE HABIT-FORMING
DESCRIPTION
The barbiturates are nonselective central nervous system (CNS)
depressants that are primarily used as
sedative-hypnotics. In subhypnotic doses, they are also used as
anticonvulsants. The barbiturates and
their sodium salts are subject to control under the Federal Controlled
Substances Act.
Phenobarbital is a barbituric acid derivative and occurs as white,
odorless, small crystals or crystalline
powder that is very slightly soluble in water; soluble in alcohol, in
ether, and in solutions of fixed alkali
hydroxides and carbonates; sparingly soluble in chloroform.
Phenobarbital is 5-ethyl-5-
phenylbarbituric acid. Phenobarbital is a substituted pyrimidine
derivative in which the basic structure is
barbituric acid, a substance that has no CNS activity. CNS activity is
obtained by substituting alkyl,
alkenyl, or aryl groups on the pyrimidine ring. It has the following
structural formula:
Each phenobarbital tablet contains 16.2 mg, 32.4 mg, 64.8 mg or 97.2
mg of phenobarbital.
In addition each tablet contains: colloidal silicon dioxide, lactose
monohydrate, magnesium stearate,
microcrystalline cellulose and sodium starch glycolate.
CLINICAL PHARMACOLOGY
Barbiturates are capable of producing all levels of CNS mood
alteration, from excitation to mild
sedation, hypnosis, and deep coma. Overdosage can produce death. In
high enough therapeutic doses,
barbiturates induce anesthesia.
Barbiturates depress the sensory cortex, decrease motor activity,
alter cerebellar function, and produce
drowsiness, sedation, and hypnosis.
Barbiturate-induced sleep differs from physiologic sleep. Sleep
laboratory studies have demonstrated
that barbiturates reduce the amount of time spent in the rapid eye
movement (REM)