PF TIAMULIN PREMIX 10% WW POWDER

מדינה: מלזיה

שפה: אנגלית

מקור: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

מרכיב פעיל:

TIAMULIN HYDROGEN FUMARATE

זמין מ:

Panfast Marketing (m) Sdn Bhd

INN (שם בינלאומי):

TIAMULIN HYDROGEN FUMARATE

יחידות באריזה:

25 kg

תוצרת:

Shennong Animal Health (Malaysia) Sdn. Bhd.

מאפייני מוצר

PF TIAMULIN PREMIX 10% W/W POWDER
[Type text]
PRODUCT REGISTRATION HOLDER:
PANFAST MARKETING (M) SDN.BHD.
PENANG SCIENCE PARK 1102, MUKIM 13, LORONG PERINDUSTRIAN BUKIT
MINYAK 18, KAWASAN PERINDUSTRIAN BUKIT MINYAK,
14100 SIMPANG AMPAT, PENANG, MALAYSIA
TEL: [phone] FAX: [phone]
MANUFACTURED BY:
SHENNONG ANIMAL HEALTH (M) SDN.BHD.
No.6, 8, 10, Jalan Industri USJ 1/19, Taman Perindustrian USJ 1
47610 SUBANG JAYA, Selangor Darul Ehsan, Malaysia.
Tel: [phone]
Fax : [phone]
COMPOSITION:
Tiamulin Hydrogen Fumarate…………………………..100mg
Exp.
Qs……………………………….………………..………………..1g
DESCRIPTION
White colour powder
PHARMACODYNAMIC
Tiamulin is a
bacteriostatic semi-synthetic antibiotic belonging to
the
pleuromutilin group of antibiotics and acts at the ribosomal level to
inhibit
bacterial protein synthesis.
Tiamulin has shown a in-vitro activity against a wide range of
bacteria
such
as
_Brachyspira _
_hyodysenteriae_,
_Brachyspira _
_pilosicoli_,
_Lawsonia _
_intracellularis_ and Mycoplasma spp.
Tiamulin is bacteriostatic at therapeutic concentrations and has been
shown to act at the 70S ribosome level and the primary binding site is
on
the 50S subunit and possibly a secondary site where the 50S and 30S
subunits
join.
It
appears
to
inhibit
microbial
protein
production
by
producing
biochemical
inactive
initiation
complexes,
which
prevent
elongation of the polypeptide chain.
Mechanisms responsible for resistance development in Brachyspira spp
to
the pleuromutilin class of antibiotics are considered to be
based on
mutations at the ribosomal target site. Clinically relevant resistance
to
tiamulin requires combinations of mutations around the tiamulin
binding
site.
Resistance to tiamulin may be associated with decreased susceptibility
to
other pleuromutilins.
PHARMACOKINETIC
Pig
Tiamulin
is
well
absorbed
in
the
pig
(over
90%)
following
oral
administration and widely distributed through the body. Tiamulin has
been shown to concentrate in the lung, a tar