PERINDOPRIL CH perindopril erbumine 8mg tablet blister pack

מדינה: אוסטרליה

שפה: אנגלית

מקור: Department of Health (Therapeutic Goods Administration)

מרכיב פעיל:

Perindopril erbumine

זמין מ:

Lupin Australia Pty Limited

INN (שם בינלאומי):

Perindopril erbumine

עלון מידע

PERINDOPRIL CH
PERINDOPRIL
(pronounced per-in-do-pril)
(Lupin Australia Pty Ltd)
CONSUMER MEDICINE
INFORMATION
WHAT IS IN THIS
LEAFLET
This leaflet answers some common
questions about PERINDOPRIL CH. It
does not contain all the available
information. It does not take the place of
talking to your doctor or pharmacist.
All medicines have risks and benefits. Your
doctor has weighed the risks of taking
PERINDOPRIL CH
against the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT TAKING
THIS MEDICINE, ASK YOUR DOCTOR OR
PHARMACIST. KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again.
WHAT PERINDOPRIL
CH IS USED FOR
PERINDOPRIL CH is
available only with a doctor's prescription.
PERINDOPRIL CH
lowers high blood pressure, a condition
which doctors call hypertension.
Everyone has blood pressure. This pressure
helps get your blood all around the body.
Your blood pressure may be different at
different times of the day, depending on
how busy or worried you are. You have high
blood pressure when your blood pressure
stays higher than is needed, even when you
are calm or relaxed.
There are usually no symptoms of high
blood pressure. The only way of knowing
that you have it is to have your blood
pressure checked on a regular basis. If high
blood pressure is not treated it can lead to
serious health problems. You may feel fine
and have no symptoms, but eventually it can
cause stroke, heart disease and kidney
failure. PERINDOPRIL CH helps lower
your blood pressure.
You may be prescribed PERINDOPRIL CH
for heart failure. Heart failure means that the
heart muscle cannot pump blood strongly
enough to supply all the blood needed
throughout the body. Heart failure is not the
same as heart attack and does not mean that
the heart stops working. Some people
develop heart failure after having had a heart
attack. However there are also other causes
of heart failure.
Heart failure may start off with no
symptoms, but as the condition progresses,
you may feel short of breath or may get tired
easily after l

מאפייני מוצר

PERINDOPRIL CH-TABLETS-PI_v3.0
Page 1 of 14
PERINDOPRIL CH TABLETS
(LUPIN AUSTRALIA PTY. LTD.)
NAME OF THE MEDICINE
Perindopril CH Tablets (Perindopril erbumine 2 mg, 4 mg and 8 mg
tablets)
CAS Registry Number: 107133-36-8
Molecular formula: C
19
H
32
N
2
O
5,
C
4
H
11
N
Chemical structure:
DESCRIPTION
Perindopril erbumine is chemically described as tert-butylammonium
(2S, 3aS, 7aS) 1 -
N [ (S)
-1-
ethoxycarbonyl butyl]-L-
alanyl) perhydroindole-2 – carboxylate. Perindopril is a dipeptide
monoacid
monoester with a perhydroindole group and no sulphydryl radical.
Perindopril erbumine is a white
powder, readily soluble in purified water, 95% ethanol and chloroform.
Perindopril erbumine has five
asymmetric centres. The drug is synthesised stereoselectively so that
it is a single enantiomer (all
S
stereochemistry).
Excipients: Lactose, microcrystalline cellulose, magnesium stearate
and silica dimethyl silylate.
PHARMACOLOGY
MECHANISM OF ACTION
Perindopril (prodrug), following hydrolysis to perindoprilat, inhibits
angiotensin converting enzyme (ACE)
both in vitro and in vivo. It is thought that ACE inhibitors reduce
blood pressure by inhibiting the enzyme
which catalyses the conversion of angiotensin I to angiotensin II.
Decreased plasma angiotensin II leads
to increased plasma renin activity and a decrease in aldosterone. In
addition to its effects on circulating
ACE, perindopril binds to and inhibits tissue converting enzyme,
predominantly in the kidney and
vascular wall. The contribution of this mechanism to the overall
antihypertensive effect of perindopril is
unknown. Animal studies have demonstrated reversal of vascular
hypertrophy and an improvement in
the ratio of elastin to collagen in the vessel wall. Studies in man
have demonstrated an improvement in
the visco-elastic properties of large vessels and in compliance.
Studies in animals and humans suggest
that specific and competitive suppression of the
renin-angiotensin-aldosterone system is the main
mechanism by which blood pressure is reduced. However,
anti