MODURET TABLET

מדינה: קנדה

שפה: אנגלית

מקור: Health Canada

מרכיב פעיל:

AMILORIDE HYDROCHLORIDE; HYDROCHLOROTHIAZIDE

זמין מ:

PREMPHARM INC

קוד ATC:

C03EA01

INN (שם בינלאומי):

HYDROCHLOROTHIAZIDE AND POTASSIUM-SPARING AGENTS

כמות:

5MG; 50MG

טופס פרצבטיות:

TABLET

הרכב:

AMILORIDE HYDROCHLORIDE 5MG; HYDROCHLOROTHIAZIDE 50MG

מסלול נתינה (של תרופות):

ORAL

יחידות באריזה:

100

סוג מרשם:

Prescription

איזור תרפויטי:

POTASSIUM-SPARING DIURETICS

leaflet_short:

Active ingredient group (AIG) number: 0213868001; AHFS:

מצב אישור:

MARKETED

תאריך אישור:

2005-04-08

מאפייני מוצר

PRODUCT MONOGRAPH
MODURET
®
(hydrochlorothiazide and
amiloride hydrochloride tablets, USP)
Each tablet contains 50 mg
of hydrochlorothiazide and
5 mg of amiloride hydrochloride
DIURETIC - ANTIHYPERTENSIVE
ORBUS PHAMRA, INC.
Date of Preparation:
MARKHAM, ONTARIO, CANADA
January 14, 1981
Date of Revision:
June 16, 2004
Control #: 092195
MODURET
®
is a Registered Trademark of Orbus Pharma, Inc.
1
PRODUCT MONOGRAPH
NAME OF DRUG
MODURET
®
(hydrochlorothiazide and
amiloride hydrochloride tablets, USP)
Each tablet contains 50 mg
of hydrochlorothiazide and
5 mg of amiloride hydrochloride
THERAPEUTIC CLASSIFICATION
Diuretic - Antihypertensive
ACTIONS AND CLINICAL PHARMACOLOGY
MODURET
®
(hydrochlorothiazide
and
amiloride
hydrochloride)
is
a
diuretic/antihypertensive
combining
the
potent
natriuretic
action
of
hydrochlorothiazide
with
the
potassium-conserving
property
of
amiloride
hydrochloride.
The
mild
diuretic
and
antihypertensive
actions
of
amiloride
hydrochloride are additive to the natriuretic, diuretic and
antihypertensive activity of
the thiazide while minimizing the loss of potassium and bicarbonate
and lessening
the likelihood of acid-base imbalance. The onset of the diuretic
action of
MODURET
®
is within 1 to 2 hours and this action appears to be sustained for
approximately 24 hours.
HYDROCHLOROTHIAZIDE
Hydrochlorothiazide is a diuretic and antihypertensive agent. It
affects the renal
tubular mechanism of electrolyte reabsorption.
Hydrochlorothiazide increases excretion of sodium and chloride in
approximately
equivalent amounts. Natriuresis may be accompanied by some loss of
potassium
2
and bicarbonate. While this compound is predominantly a saluretic
agent, in vitro
studies have shown that it has a carbonic anhydrase inhibitory action
which seems
to be relatively specific for the renal tubular mechanism. It does not
appear to be
concentrated in erythrocytes or the brain in sufficient amounts to
influence the
activity of carbonic anhydrase in those tissues.
Hydrochlorothiazide is useful in the treatment of hy