מדינה: מלזיה
שפה: אנגלית
מקור: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
MEFENAMIC ACID
KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.
MEFENAMIC ACID
20 Capsules; 1000 Capsules; 10 Capsules; 100 Capsules
KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ MEFEMIN MEFENAMIC ACID 250MG CAPSULES Mefenamic Acid (250mg) 1 WHAT IS IN THIS LEAFLET 1. What MEFEMIN is used for 2. How MEFEMIN works 3. Before you use MEFEMIN 4. How to use MEFEMIN 5. While you are using MEFEMIN 6. Side effects 7. Storage and Disposal of MEFEMIN 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision 11. Serial Number WHAT MEFEMIN IS USED FOR Mefenamic acid is used to relieve: Pain due to rheumatoid arthritis including Still's Disease, Pain due to osteoarthritis, Muscle pain, Trauma-related pain, Pain after injury, Toothaches, Headaches, Pain following an operation, Pain after childbirth, Painful menstruation (dysmenorrhea), Pre-menstrual syndrome Abnormally heavy bleeding due to dysfunctional causes or the presence of an intrauterine device (IUD) Fever in children over 6 months of age. HOW MEFEMIN WORKS MEFEMIN contains mefenamic acid as the active ingredient. It has non-steroidal anti-inflammatory drug (NSAID) with anti- inflammatory, analgesic and antipyretic properties. Mefenamic acid inhibits the action of chemical called prostaglandin. BEFORE YOU USE MEFEMIN _-When you must not use it _ Tell your doctor before using MEFEMIN if you are hypersensitive to mefenamic acid or any of the excipients. have active or history of recurrent peptic ulcer/haemorrhage have shown hypersensitivity reactions in response to ibuprofen, aspirin, or other non-steroidal anti- inflammatory drugs. have severe hepatic, renal and cardiac failure. are pregnant and are in the last trimester of pregnancy. have history of gastrointestinal bleeding or perforation, and inflammatory bowel disease. are going through pain treatment after coronary artery bypass graft (CABG) surgery. _-Pregnancy and lactation _ Tell your doctor or pharmacist if you are pregnant, planning to get pregnant or breast-feeding before using MEFEMIN. It is advised that mefenamic aci קרא את המסמך השלם
MEFEMIN MEFENAMIC ACID 250MG CAPSULES NAME AND STRENGTH OF ACTIVE SUBSTANCES Each capsule contains: Mefenamic acid…………………………. 250mg PRODUCT DESCRIPTION Blue cap ivory body capsule PHARMACODYNAMICS Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) with anti- inflammatory, analgesic and antipyretic properties. Mefenamic acid inhibits the action of prostaglandin synthetase (cyclooxygenase). This results in a reduction in the rate of prostaglandin synthesis and reduced prostaglandin levels. PHARMACOKINETICS _Absorption and Distribution _ Mefenamic acid is absorbed from the gastro intestinal tract. Peak levels of 10 mg/l occur two hours after the administration of a 1g oral dose to adults. _Biotransformation _ Mefenamic acid is predominantly metabolised by cytochrome P450 enzyme CYP2C9 in the liver, first to a 3-hydroxymethyl derivative (metabolite I) and then a 3-carboxyl derivative (metabolite II). Both metabolites undergo secondary conjugation to form glucuronides. Therefore, in patients who are known or suspected to be poor CYP2C9 metabolisers based on previous history/experience with other CYP2C9 substrates, mefenamic acid should be administered with caution as they may have abnormally high plasma levels due to reduced metabolic clearance. _Elimination _ Fifty two percent of a dose is recovered from the urine, 6% as mefenamic acid, 25% as metabolite I and 21% as metabolite II. Assay of stools over a 3-day period accounted for 10-20 % of the dose chiefly as unconjugated metabolite II. The plasma levels of unconjugated mefenamic acid decline with a half life of approximately two hours. INDICATIONS Mefenamic acid is indicated for: 1) The symptomatic relief of rheumatoid arthritis (including Still's Disease), osteoarthritis, and pain including muscular, traumatic and dental pain, headaches of most etiology, post-operative and postpartum pain 2) The symptomatic relief of primary dysmenorrhea 3) Menorrhagia due to dysfunctional causes or the presence of an intrauterine device (IUD) wh קרא את המסמך השלם