מדינה: אוסטרליה
שפה: אנגלית
מקור: Department of Health (Therapeutic Goods Administration)
Gemfibrozil
Pfizer Australia Pty Ltd
Medicine Registered
LOPID ® _Gemfibrozil_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some of the more common questions about LOPID. It does not contain all of the available information. It does not take the place of talking with your doctor and pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking LOPID against the benefits he/she expects it will have for you. ASK YOUR DOCTOR OR PHARMACIST IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE. KEEP THIS INFORMATION WITH YOUR MEDICINE. You may want to read it again later. WHAT LOPID IS USED FOR _WHAT LOPID DOES_ LOPID helps to lower high triglycerides, cholesterol and other fats. It should be used in conjunction with a low fat diet. LOPID is used in patients with pancreatitis (inflammation of the pancreas) to lower very high levels of triglycerides when strict diet control has not been adequate. LOPID can also be used to control fats in the blood in diabetic patients, and reduce the risk of heart diseases such as angina and heart attacks in patients with high levels of cholesterol. _WHAT IS CHOLESTEROL AND_ _TRIGLYCERIDES_ Everyone has cholesterol in their blood. It is a type of blood fat needed by the body. Cholesterol has many functions; these include building cell membranes, making bile acids (which help digest food) and producing some essential hormones. However, too much cholesterol can be a problem. Cholesterol is present in many foods and is also made in your body by the liver. If your body does not balance the amount of cholesterol it needs with the amount of cholesterol eaten, then your cholesterol levels become too high. High cholesterol is more likely to occur with certain diseases or if you have a family history of high cholesterol. There are different types of cholesterol. LDL cholesterol is the "bad" cholesterol that can block your blood vessels. HDL cholesterol is the "good" cholesterol that is thought to remove the bad cholesterol from the blood vessels. When you have high leve קרא את המסמך השלם
Version: pfplopit10813 Supersedes: pfplopit11009 Page: 1 of 13 PRODUCT INFORMATION LOPID ® (GEMFIBROZIL) NAME OF MEDICINE LOPID (gemfibrozil) 600 mg tablets. LOPID contains the active ingredient gemfibrozil. Gemfibrozil is a nonhalogenated phenoxypentanoic acid with the following structural formula: - O - C H 2 - C H 2 - C H 2 - C - C O O H C H 3 C H 3 C H 3 C H 3 Chemical name: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid Molecular formula: C 15 H 22 0 3 Molecular weight: 250.35 CAS registry number: 25812-30-0. DESCRIPTION Gemfibrozil is a white, waxy powder which is stable under ordinary conditions. The melting point is 58-61 C. Its solubility is 0.0019% (w/v) in water and in acid and over 1% in dilute base. Each film-coated tablet contains 600 mg gemfibrozil. LOPID tablets also contain colloidal anhydrous silica, pregelatinised starch, polysorbate 80, microcystalline cellulose, hypromellose, calcium stearate, hydroxypropylcellulose, methyl hydroxybenzoate, propyl hydroxybenzoate, macrogol 3500, opaspray white and candelilla wax. PHARMACOLOGY MECHANISM OF ACTION LOPID's mechanism of action has not been definitely established. In man, LOPID inhibits peripheral lipolysis and decreases the hepatic extraction of free fatty acids, thus reducing hepatic triglyceride production. LOPID also inhibits synthesis and increases clearance of apolipoprotein B, which is a carrier of VLDL, leading to a decrease in VLDL production. LOPID is a lipid regulating agent which decreases serum triglycerides and total cholesterol, and increases high density lipoprotein cholesterol (HDL-chol קרא את המסמך השלם