מדינה: אוסטרליה
שפה: אנגלית
מקור: Department of Health (Therapeutic Goods Administration)
ipratropium bromide monohydrate
Pfizer Australia Pty Ltd
Registered
IPRAVENT ® _INHALATION SOLUTION_ _Ipratropium bromide_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Ipravent. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT USING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT IPRAVENT INHALATION SOLUTION IS USED FOR Ipravent belongs to a group of medicines known as anticholinergic bronchodilators. Anticholinergic bronchodilators work by relaxing the bronchial tubes (air passages) that carry air in and out of your lungs. This makes breathing less difficult. Ipravent is used to relieve the symptoms of lung disease such as asthma or chronic obstructive bronchitis. It may be used in other conditions where breathing is difficult, such as after surgery or during assisted ventilation. Ipravent may be used for the management of other conditions that are not mentioned above. Your doctor will be able to tell you about the specific condition for which you have been prescribed Ipravent. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY IT HAS BEEN PRESCRIBED FOR YOU. This medicine is available only with a doctor's prescription. BEFORE YOU USE IT _WHEN YOU MUST NOT USE IT_ DO NOT USE IPRAVENT IF YOU HAVE AN ALLERGY TO IPRATROPIUM BROMIDE OR ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET. IF YOU ARE NOT SURE IF THIS APPLIES TO YOU, CHECK WITH YOUR DOCTOR. IPRAVENT SHOULD NOT BE GIVEN TO A NEWBORN BABY. DO NOT USE IT AFTER THE EXPIRY DATE (EXP) PRINTED ON THE PACK. If you use it after the expiry date has passed, it may not work as well. DO NOT USE IT IF THE PACKAGING IS TORN OR SHOWS SIGNS OF TAMPERING. _BEFORE YOU START TO USE IT_ TELL YOUR DOCTOR IF 1. YOU HAVE ANY ALLERGIES TO: • any other medic קרא את המסמך השלם
Version: pfpipraj10512 Supersedes: pupiprau10807 Page 1 of 8 PRODUCT INFORMATION IPRAVENT ® INHALATION SOLUTION – UNIT DOSE NAME OF THE MEDICINE Ipratropium Bromide BP Ipratropium bromide is a quaternary isopropyl derivative of atropine. Its chemical name is (1R, 3r, 5S, 8r)-3-[(RS) - (3 - hydroxy - 2 - phenylpropanoyl) oxy] - 8 - methyl - 8 - (1 - methylethyl) - 8 - azoniabicyclo [3.2.1] octane bromide. It appears as a white or almost white, crystalline powder, soluble in water, freely soluble in methanol and slightly soluble in alcohol. The addition of an N-isopropyl group distinguishes the molecule from atropine and is responsible for a lower lipid solubility. The structural formula is represented below. Molecular Formula: C 20 H 30 BrNO 3 Molecular Weight: 412.4 CAS Number: 22254-24-6 DESCRIPTION Ipravent Inhalation Solution in Sterinebs is a clear, colourless to almost colourless, sterile solution. It contains ipratropium bromide monohydrate 261 g/mL equivalent to 250 g ipratropium bromide (anhydrous) or ipratropium bromide monohydrate 522 g/mL equivalent to 500 g ipratropium bromide (anhydrous) and Sodium Chloride BP in Water for Injections BP. It does not contain preservatives. Version: pfpipraj10512 Supersedes: pupiprau10807 Page 2 of 8 PHARMACOLOGY CLASS OF DRUG Anticholinergic bronchodilator. MODE OF ACTION Ipratropium bromide allows bronchodilation by inhibiting cholinergic bronchomotor tone and consequently, vagal reflexes mediating bronchoconstriction are blocked. In this respect ipratropium bromide is fundamentally different from agonists. The onset of bronchodilator response is seen within three to five minutes of administration. Peak response is reached 1.5 to 2 hours after inhalation. The duration of significant bronchodilator action is up to 6 hours. Ipravent can be used in combination with agonists. There is evidence that in patients who respond to ipratropium bromide greater relief of bronchospasm can be achieved by the concurrent use of ipratropium bromide, and agonists, as compared to tha קרא את המסמך השלם