FUROSEMIDE 1%- furosemide syrup

מדינה: ארצות הברית

שפה: אנגלית

מקור: NLM (National Library of Medicine)

מרכיב פעיל:

FUROSEMIDE (UNII: 7LXU5N7ZO5) (FUROSEMIDE - UNII:7LXU5N7ZO5)

זמין מ:

Cronus Pharma LLC

מסלול נתינה (של תרופות):

ORAL

סוג מרשם:

PRESCRIPTION

סממני תרפויטית:

Dog: Furosemide is an effective diuretic possessing a wide therapeutic range. Pharmacologically it promotes the rapid removal of abnormally retained extracellular fluids. The rationale for the efficacious use of diuretic therapy is determined by the clinical pathology producing the edema. Furosemide Syrup 1% is indicated for the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema. The continued use of heart stimulants, such as digitalis or its glycosides, is indicated in cases of edema involving cardiac insufficiency. Furosemide Syrup 1% is a highly effective diuretic-saluretic which if given in excessive amounts may result in dehydration and electrolyte imbalance. Therefore, the dosage and schedule may have to be adjusted to the patients' needs. The animal should be observed for early signs of electrolyte imbalance, and corrective measures administered. Early signs of electrolyte imbalance are: Increased thirst, lethargy, drowsiness

leaflet_short:

Furosemide Syrup 1% (10 mg/mL), available in 60 mL bottles with calibrated safety dropper.

מצב אישור:

Abbreviated New Animal Drug Application

מאפייני מוצר

FUROSEMIDE 1%- FUROSEMIDE SYRUP
CRONUS PHARMA LLC
----------
FUROSEMIDE SYRUP 1%
ANADA NO: 200-382, APPROVED BY FDA
For Use In Dogs Only
A diuretic-saluretic for prompt relief of edema
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed
veterinarian.
DESCRIPTION
Furosemide is a chemically distinct diuretic and saluretic
pharmacodynamically
characterized by the following:
1.A high degree of efficacy, low-inherent toxicity and a high
therapeutic index.
2.A rapid onset of action of comparatively short duration.
3.A pharmacologic action in the functional area of the nephron, i.e.,
proximal and distal
tubules and the ascending limb of the loop Henle.
4.A dose-response relationship and a ratio of minimum to maximum
effective dose
range greater than ten fold.
5.It is administered orally. It is readily absorbed from the
intestinal tract and well
tolerated.
THE CAS REGISTRY NUMBER IS: 54-31-9
This product contains alcohol 11.5%, USP as a preservative, and FD&C
Yellow #6 and
D&C Yellow #10 as color additives.
Furosemide, a diuretic, is an anthranilic acid derivative with the
following structural
formula;
GENERIC NAME: Furosemide (except in United Kingdom-frusemide).
Chemical name: 4-
chloro-N-furfuryl-5-sulfamoylanthranilic acid.
ACTIONS
The therapeutic efficacy of furosemide is from the activity of the
intact and unaltered
molecule throughout the nephron, inhibiting the reabsorption of sodium
not only in the
proximal and distal tubule, but also in the ascending limb of the loop
of Henle. The
1-2
2-4
1-2
prompt onset of action is a result of the drug's rapid absorption and
a poor lipid
solubility. The low lipid solubility and a rapid renal excretion
minimizes the possibility of
lipid accumulation in tissues and organs or of crystalluria.
Furosemide has no inhibitory
effect on carbonic anhydrase or aldosterone activity in the distal
tubule. The drug
possesses diuretic activity in the presence of either acidosis or
alkalosis.
INDICATIONS
DOG: Furosemide is an effective diuretic possessing a wide