EPINEPHRINE- epinephrine injection, solution

מדינה: ארצות הברית

שפה: אנגלית

מקור: NLM (National Library of Medicine)

מרכיב פעיל:

EPINEPHRINE (UNII: YKH834O4BH) (EPINEPHRINE - UNII:YKH834O4BH)

זמין מ:

Cardinal Health

מסלול נתינה (של תרופות):

INTRAVENOUS

סוג מרשם:

PRESCRIPTION DRUG

סממני תרפויטית:

Epinephrine Injection, USP is indicated for intravenous injection in (1) treatment of acute hypersensitivity (anaphylactoid reactions to drugs, animal serums and other allergens), (2) treatment of acute asthmatic attacks to relieve bronchospasm not controlled by inhalation or subcutaneous administration of other solutions of the drug and (3) treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular (A-V) heart block with syncopal seizures (Stokes-Adams Syndrome). In acute attacks of ventricular standstill, physical measures should be applied first. When external cardiac compression and attempts to restore the circulation by electrical defibrillation or use of a pacemaker fail, intracardiac puncture and intramyocardial injection of epinephrine may be effective. Epinephrine is contraindicated in patients with known hypersensitivity to sympathomimetic amines, in patients with angle closure glaucoma, and patients in shock (nonanaphylactic). It should not be used in patients anesthetiz

leaflet_short:

Epinephrine Injection, USP is supplied in single-dose containers as follows: List No. Container Type Size Concentration Total Content (Epinephrine) Overbagged with 1 vial per bag NDC# 55154-3195-8 Abboject® Syringe* 18-G 3½ inch (intracardiac) 10 mL 0.1 mg/mL 1 mg                     Overbagged with 1 vial per bag NDC# 55154-3186-8 Abboject® LifeShield® Syringe*** 20-G 10 mL 0.1 mg/mL 1 mg               *  Abboject® Unit of Use Syringe   **  Abboject® LifeShield® Unit of Use Syringe with protected needle ***  Abboject® LifeShield® Unit of Use Syringe with protected needle and male luer lock adapter. Store at 20 to 25ºC (68 to 77ºF). [See USP Controlled Room Temperature.] Protect from light. TO PREVENT NEEDLE-STICK INJURIES, NEEDLES SHOULD NOT BE RECAPPED, PURPOSELY BENT OR BROKEN BY HAND. Revised: 3/2016                                                                               EN-4131 Hospira, Inc., Lake Forest, IL 60045 USA                                                                                          Abboject™ is a trademark of Abbott Laboratories. Repackaged By: Cardinal Health Zanesville, OH 43701 IA6404 0217

מצב אישור:

unapproved drug other

מאפייני מוצר

EPINEPHRINE- EPINEPHRINE INJECTION, SOLUTION
CARDINAL HEALTH
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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EPINEPHRINE
INJECTION, USP
1 MG/10 ML (0.1 MG/ML)
ABBOJECT™ SYRINGE
FLIPTOP VIAL
PROTECT SOLUTION FROM LIGHT;
DO NOT USE THE INJECTION IF ITS COLOR IS
PINKISH OR DARKER THAN SLIGHTLY YELLOW
OR IF IT CONTAINS A PRECIPITATE.
Rx only
_DESCRIPTION_
Epinephrine Injection, USP is a sterile, nonpyrogenic solution
administered parenterally by the
intravenous or intracardiac (left ventricular chamber) routes, or via
endotracheal tube into the bronchial
tree.
Each milliliter (mL) contains epinephrine 0.1 mg; sodium chloride 8.16
mg; sodium metabisulfite added
0.46 mg; citric acid, anhydrous 2 mg and sodium citrate, dihydrate 0.6
mg added as buffers. May contain
additional citric acid and/or sodium citrate for pH adjustment. pH 3.3
(2.2 to 5.0). Epinephrine Injection,
USP is oxygen sensitive.
The solution contains no bacteriostat or antimicrobial agent and is
intended for use only as a single-dose
injection. When smaller doses are required the unused portion should
be discarded.
Epinephrine Injection, USP is a parenteral adrenergic
(sympathomimetic) agent and cardiac stimulant.
The drug belongs to the group of endogenous compounds known as
catecholamines.
Sodium Chloride, USP is chemically designated NaCl, a white
crystalline powder freely soluble in
water.
Epinephrine, USP is chemically designated 4-[1-hydroxy-2-(methylamino)
ethyl]-1, 2 benzenediol, a
white, microcrystalline powder. With acids, it forms salts that are
freely soluble in water. Epinephrine
has the following structural formula:
_CLINICAL PHARMACOLOGY_
The actions of epinephrine resemble the effects of stimulation of
adrenergic nerves. To a variable
degree it acts on both alpha and beta receptor sites of sympathetic
effector cells. Its most prominent
actions are on the beta receptors of the heart, vascul