Eficur 50 mgmo ceftiofur suspension for injection for cattle and swine

מדינה: מלזיה

שפה: אנגלית

מקור: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

מרכיב פעיל:

CEFTIOFUR

זמין מ:

Hipra Malaysia Sdn Bhd

INN (שם בינלאומי):

CEFTIOFUR

יחידות באריזה:

250.00 mcg/mL; 100.00 mcg/mL; 100 ml; 250 ml; 100 and 250 ml; 50 ml

תוצרת:

Laboratorios Hipra, S.A.

מאפייני מוצר

705099-03.1
02-19
EFICUR
50 mg/ml ceftiofur suspension for injection for swine and cattle
COMPOSITION PER ML:
Ceftiofur (as hydrochloride) 50 mg
Oil based vehicle q.s. ad.
1 ml
PHARMACODYNAMICS
AND
PHARMACOKINETICS
PROPERTIES:
Ceftiofur is a late generation cephalosporin, which is
active
against
Gram-positive
and
Gram-negative
bacteria.
Like
all
beta-lactam
antibiotics,
ceftiofur
inhibits bacterial cell wall synthesis, thereby exerting
bactericidal properties.
Cell wall synthesis is dependent on enzymes that are
called penicillin-binding proteins (PBP´s). Bacteria may
develop
resistance
to
cephalosporins
by
1)
having
penicillin binding proteins insensitive to an otherwise
effective
β-lactam;
2)
altering
cell
permeability
to
β--lactams; 3) producing β-lactamases that cleave the
β--lactam ring of the antibiotic, or 4) active efflux.
Some β--lactamases, documented in Gram-negative enteric organisms,
may lead to
varying degrees of cross resistance between cephalosporins, as well as
with
penicillins, ampicillins and β-lactam inhibitor combinations.
Ceftiofur is active against the following microorganisms which are
involved in
respiratory
diseases
in
swine:
_Pasteurella _
_multocida, _
_Actinobacillus _
_pleuropneumoniae _and _Streptococcus suis. Bordetella bronchiseptica_
is intrinsically
non-susceptible to ceftiofur.
It is also active against bacteria involved in respiratory disease in
cattle: _Pasteurella _
_multocida, Mannheimia haemolytica_), _ Haemophilus somnus_; bacteria
involved in
acute bovine foot rot (interdigital necrobacillosis): _ Fusobacterium
necrophorum, _
_Bacteroides _
_melaninogenicus_
(_Porphyromonas _
_asaccharolyitica_);
and
bacteria
associated with acute post-partum (puerperal) metritis in cattle: _
Escherichia coli, _
_Arcanobacterium pyogenes_ and _Fusobacterium necrophorum_.
After administration, ceftiofur is quickly metabolised to
desfuroylceftiofur, the
principal active metabolite.
Desfuroylceftiofur has an equivalent anti-microbial activity to
ceftiofur against the
bacteria involve