DOXORUBICIN

עלון מידע

DOXORUBICIN SZ
Doxorubicin Hydrochloride Concentrated Injection

CONSUMER MEDICINE INFORMATION

Version 1.2

DOXORUBICIN SZ
                Page 1 of 6

WHAT IS IN THIS LEAFLET
_ _
PLEASE READ THIS LEAFLET
CAREFULLY BEFORE TREATMENT
WITH DOXORUBICIN SZ.

This leaflet answers some
common questions about this
medicine.

It does not contain all the
available information.

It does not take the place of
talking to your doctor.

All medicines have risks and
benefits. Your doctor has
weighed the risks of you
taking this medicineagainst
the benefits expected for you.

IF YOU HAVE ANY CONCERNS
ABOUT TAKING THIS MEDICINE,
ASK YOUR DOCTOR OR
PHARMACIST.
PLEASE KEEP THIS LEAFLET.

You may need to read it again.

WHAT
DOXORUBICIN
SZIS USED FOR

DOXORUBICIN SZ is used
to treat certain cancers.

This medicine belongs to a
group of medicines called
antineoplastic or cytotoxic
medicines. You may also hear
of these being called
chemotherapy medicines.

DOXORUBICIN SZ is
thought to work by killing
cancer cells, and stopping
cancer cells from growing and
multiplying.It contains the
active ingredient doxorubicin
hydrochloride.

Your doctor may have
prescribed DOXORUBICIN
SZ for another reason. Ask
your doctor if you have any
questions about why this
medicine has been prescribed
for you.

DOXORUBICIN SZ is not
addictive. This medicine is
available only with a doctor’s
prescription.

DOXORUBICIN SZ is to be
given only under the strict
supervision of your doctor.

BEFORE YOU ARE GIVEN
DOXORUBICIN SZ
_ _
_WHEN YOU MUST NOT BE _
_GIVEN IT_

YOU MUST NOT BE GIVEN
DOXORUBICIN SZ IF YOU
HAVE AN ALLERGY TO
DOXORUBICIN HYDROCHLORIDE
OR ANY OF THE INGREDIENTS
LISTED AT THE END OF THIS
LEAFLET

Symptoms of an allergic
reaction to DOXORUBICIN
SZmay include:
  shortness of

קרא את המסמך השלם

מאפייני מוצר

_Product Information _
_Doxorubicin SZ Concentrated Injection 10 mg/5 mL
and 200 mg/100 mL
      _
_Page1 _
_Sandoz Pty Ltd _
_Version 1.2 _
_ _

PRODUCT INFORMATION

DOXORUBICIN SZ 10MG/5ML, 200MG/100MLCONCENTRATED
INJECTION

NAME OF THE MEDICINE

Doxorubicin hydrochloride

ChemicalName:(8S,10S)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)-oxy]-8-
glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-
naphthacenedionehydrochloride.

Molecular Formula: C
27
H
29
NO
11
HCl
Molecular Weight: 579.99
CAS Number: 25316-40-9

Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic
isolated from cultures of
_Streptomyces peucetius var. caesius._ The chemical structure of
doxorubicin consists of a
tetracyclic ring, with the sugar daunosamine attached by a glycosidic
linkage.

Structurally, doxorubicin is related to daunomycin (daunorubicin) and
differs only in hydroxyl
group substitution (instead of hydrogen) at the alkyl side chain, at
position ‘9’ of the ‘A’ ring.

ITS STRUCTURAL FORMULA IS AS FOLLOWS:

DESCRIPTION:
_Product Information _
_Doxorubicin SZ Concentrated Injection 10 mg/5 mL
and 200 mg/100 mL
      _
_Page2 _
_Sandoz Pty Ltd _
_Version 1.2 _
_ _

Doxorubicin hydrochloride
is soluble in water; slightly soluble in methanol
; practically insoluble
in acetone and in ethanol.

Doxorubicin hydrochloride concentrated injection is a sterile, red
colored, clear solution of
doxorubicin hydrochloride and sodium chloride in water for
injections. Hydrochloric acid is
added as necessary to adjust the pH.

PHARMACOLOGY

Though not completely elucidated, the mechanism of action of
doxorubicinis related to its ability
to bind to DNA and inhibit nucleic acid synthesis. Cell culture
studies have demonstrated rapid
cell penetration and perinucleolar chromatin bi

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DOXORUBICIN SZ

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