מדינה: אוסטרליה
שפה: אנגלית
מקור: Department of Health (Therapeutic Goods Administration)
Citalopram hydrobromide
Ranbaxy Australia Pty Ltd
Medicine Registered
CELICA CMI V8 Jan 2012 1 CELICA _CITALOPRAM (AS CITALOPRAM HYDROBROMIDE) 20 MG TABLETS_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about CELICA. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you using CELICA against the benefits it is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT USING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. Keep this leaflet with the medicine. You may need to read it again. WHAT CELICA IS USED FOR CELICA is used to treat depression. It belongs to a group of medicines called selective serotonin reuptake inhibitors (SSRIs). They are thought to work by their actions on brain chemicals called amines which are involved in controlling mood. Depression is longer lasting or more severe than the “low moods” everyone has from time to time due to the stress of everyday life. It is thought to be caused by a chemical imbalance in parts of the brain. This imbalance affects your whole body and can cause emotional and physical symptoms such as feeling low in spirit, loss of interest in activities, being unable to enjoy life, poor appetite or overeating, disturbed sleep, often waking up early, loss of sex drive, lack of energy and feeling guilty over nothing. CELICA corrects this chemical imbalance and may help relieve the symptoms of depression. Your doctor, however, may prescribe it for another purpose. Ask your doctor if you have any questions about why it has been prescribed for you. This medicine is only availab קרא את המסמך השלם
CELICA PI V8 Jan 2012 CELICA TABLETS NAME OF THE MEDICINE Citalopram hydrobromide CHEMICAL NAME: 1-(3-dimethylaminopropyl)-1-(4-flurophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrobromide. The active is present as a racemate. CAS NUMBER: [59729-32-7] MOLECULAR FORMULA: C 20 H 21 FN 2 O 1 HBr MOLECULAR WEIGHT: 405.32 STRUCTURAL FORMULA: DESCRIPTION Citalopram hydrobromide is a fine white to off-white, crystalline material. Citalopram hydrobromide is sparingly soluble in water, soluble in ethanol (96%), freely soluble in chloroform and very slightly soluble in diethyl ether. No polymorphic forms have been detected. Each film-coated tablet of CELICA contains 20 mg citalopram (as hydrobromide) and the following excipients: lactose, maize starch, copovidone, croscarmellose sodium, microcrystalline cellulose, magnesium stearate and Opadry complete film coating system 03B58902 white. PHARMACOLOGY Pharmacological actions Biochemical and behavioural studies have shown that citalopram is a potent inhibitor of serotonin (5-HT)-uptake. Tolerance to the inhibition of 5-HT-uptake is not induced by long-term treatment with citalopram. On the basis of in vitro studies, citalopram is one of the most selective Serotonin Reuptake Inhibitor (SSRI) yet developed, with no, or minimal effect on noradrenaline (NA), dopamine (DA) and gamma aminobutyric acid (GABA) uptake. In comparison with other SSRI’s the decreasing order of selectivity is escitalopram, citalopram, sertraline, paroxetine, fluvoxamine and fluoxetine. The clinical relevance of this in vitro finding has not been established. CELICA PI V8 Jan 2012 Page 2 of 16 In contrast to many tricyclic antidepressants and some of the newer SSRIs , citalopr קרא את המסמך השלם