מדינה: פיליפינים
שפה: אנגלית
מקור: FDA (Food And Drug Administration)
Clotrimazole
Glenmark Philippines, Inc.; Distributor: Glenmark Philippines, Inc.
Clotrimazole
2% w / w (20mg / g)
Vaginal Gel
Aluminum Collapsible Tube with applicator x 30g (Box of 1's)
Glenmark Pharmaceuticals Ltd., India
2017-01-24
Tube Applicator with cylinder & plunger Cylinder Plunger Bladder Womb Vagina SAME SIZE ARTWORK LEAFLET SIZE: 140 mm x 176 mm FORMULATION: Each gram contains Clotrimazole 20mg (2% w/w) DESCRIPTION CANDIVA V Gel is an imidazole antifungal drug for vaginal use in candidial vulvovaginitis. Clotrimazole was first synthesized in 1967 and has the chemical name 1-(o-chloro-diphenyl-benzyl) imidazole. The molecular formula of Clotrimazole is C H ClN with a molecular weight of 344.8. The chemical 22 17 2 structure is as follows: CLINICAL PHARMACOLOGY PHARMACODYNAMICS _MECHANISM OF ACTION_ Clotrimazole, an imidazole derivative, exerts antifungal effects by inhibition of fungal sterol synthesis. Clotrimazole appears to inhibit the enzymatic conversion of 2,4-methylenedihydrolanosterol to demethylsterol, the precursor to ergosterol, which is an essential building block of the cytoplasmic membrane of the fungi. At minimum fungicidal concentrations, Clotrimazole causes leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. Its postulated action has also been described as resulting in leakage of essential intracellular components leading to inhibition of synthesis of such macromolecules as protein, lipid, DNA, and polysaccharides. Other proposed mechanisms for antimycotic activity of Clotrimazole include alteration of plasma membrane ATPase, alteration of other membrane enzymes, alterations in membrane transport, and fatty acid metabolism. ANTIMICROBIAL SPECTRUM _FUNGI:_ Clotrimazole is a broad spectrum antifungal agent that inhibits the growth of most fungi pathogenic to man, including the following: _a) Blastomyces dermatitidis _ _b) Candida spp: _Clotrimazole is as active as nystatin against_ Candida spp _ _c) Coccidioides immitis _ _d) Cryptococcus neoformans (Torula histolytica) _ _e) Dermatophytes (Trichophyton, Microsporum, Epidermophyton) _ _f) Histoplasma capsulatum _ _g) Malassezia furfur _ _h) Naegleria fowleri_ _i) N קרא את המסמך השלם