מדינה: קנדה
שפה: אנגלית
מקור: Health Canada
PROPRANOLOL HYDROCHLORIDE
APOTEX INC
C07AA05
PROPRANOLOL
20MG
TABLET
PROPRANOLOL HYDROCHLORIDE 20MG
ORAL
100/1000
Prescription
BETA-ADRENERGIC BLOCKING AGENTS
Active ingredient group (AIG) number: 0101831005; AHFS:
APPROVED
2021-01-29
Page 1 of 26 PRODUCT MONOGRAPH Pr APO-PROPRANOLOL (Propranolol Hydrochloride) (10, 20, 40, 80 and 120 mg Tablets) USP Beta-Adrenergic Receptor Blocking Agent APO TEX INC., Toronto, Ontario M9L 1T9 DATE OF REVISION: 29 January 2021 Control Number: 242932 Page 2 of 26 NAME OF DRUG Pr APO-PROPRANOLOL (Propranolol Hydrochloride) (10, 20, 40, 80 and 120 mg Tablets) USP PHARMACOLOGIC CLASSIFICATION Beta-adrenergic receptor blocking agent ACTIONS APO-PROPRANOLOL (propranolol hydrochloride) is a beta-adrenergic receptor blocking agent. It has no other autonomic nervous system activity. Propranolol hydrochloride is a competitive antagonist which specifically competes with beta-adrenergic receptor stimulating agents for available beta receptor sites. When access to beta-adrenergic receptor sites is blocked by propranolol hydrochloride, the chronotropic, inotropic, and vasodilator responses to beta-adrenergic stimulation are decreased proportionately. Beta-adrenergic blockade is useful in some clinical conditions in which sympathetic activity is excessive or inappropriate, and therefore detrimental to the patient. Sympathetic stimulation is however, vital in some situations, (e.g. in patients with A-V block or with a severely damaged: heart) and should, be preserved. The basic objective of beta-adrenergic blockade is to decrease adverse sympathetic stimulation but not to the degree that impairs necessary sympathetic support. Beta-blockade results in bronchial constriction by interfering with endogenously or exogenously induced bronchodilation. (See CONTRAINDICATIONS and WARNINGS). The mechanism of the antihypertensive effects of propranolol hydrochloride has not been established. Among the factors that may be involved are (1) decreased cardiac output, (2) inhibition of renin release by the kidneys, and (3) diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain. It has been suggested, but not established, that propranolol hydrochloride may achieve a better antihypertensive effect in patients with n קרא את המסמך השלם