Pays: États-Unis
Langue: anglais
Source: NLM (National Library of Medicine)
milbemycin oxime (UNII: 0502PUN0GT) (milbemycin oxime - UNII:0502PUN0GT), lufenuron (UNII: 1R754M4918) (lufenuron - UNII:1R754M4918)
Merck Sharp & Dohme Corp.
ORAL
PRESCRIPTION
SENTINEL FLAVOR TABS are indicated for use in dogs and puppies, four weeks of age and older, and two pounds body weight or greater. SENTINEL FLAVOR TABS are also indicated for the prevention of heartworm disease caused by Dirofilaria immitis, for the prevention and control of flea populations, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxascaris leonina (roundworm) and Trichuris vulpis (whipworm) infections. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. Concurrent use of an adulticide product may be necessary for adequate control of adult fleas. Without concurrent use of an adulticide, adequate flea control may not be achieved in dogs that have repeated exposure to flea infested animals or environments.
SENTINEL FLAVOR TABS are available in four tablet sizes (see Dosage section) formulated according to the weight of the dog. Each tablet size is available in color-coded packages of 6 or 12 tablets each, which are packaged 10 per display carton. Store in a dry place at controlled room temperature, between 59° and 77°F (15-25°C).
New Animal Drug Application
SENTINEL FLAVOR TABS- MILBEMYCIN OXIME AND LUFENURON TABLET, CHEWABLE MERCK SHARP & DOHME CORP. ---------- SENTINEL FLAVOR TABS (MILBEMYCIN OXIME+LUFENURON) The palatable once-a-month prescription tablet that prevents heartworm disease and flea populations in dogs and puppies. SENTINEL FLAVOR TABS (milbemycin oxime/lufenuron) also control flea populations and adult hookworms, and remove and control adult roundworm and whipworm infections in dogs and puppies. CAUTION Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. WARNINGS Not for human use. Keep this and all drugs out of the reach of children. DESCRIPTION SENTINEL FLAVOR TABS are available in four tablet sizes in color-coded packages for oral administration to dogs and puppies according to their weight. (See Dosage Section). Each tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime and 4.55 mg/pound (10 mg/kg) body weight of lufenuron. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A (C H NO , MW 555.71) and 20% A (C H NO , MW 541.68). Milbemycin oxime is classified as a macrocyclic anthelmintic. Lufenuron is a benzoylphenylurea derivative with the following chemical composition: N- [2,5-dichloro-4-(1,1,2,3,3,3,-hexafluoropropoxy)-phenylaminocarbonyl]-2,6- difluorobenzamide (C H Cl F N O , MW 511.15). Benzoylphenylurea compounds, including lufenuron, are classified as insect development inhibitors (IDIs). MODE OF ACTION Milbemycin oxime, one active ingredient in SENTINEL FLAVOR TABS, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm (_Ancylostoma caninum_), roundworm (_Toxocara canis_ and _Toxascaris leonina_) and whipworm (_Trichuris vulpis_) infestations when administered orally according to the recommended dosage schedule. Lufenuron, the other active ingredient in S Lire le document complet