SENTINEL FLAVOR TABS- milbemycin oxime and lufenuron tablet, chewable

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

milbemycin oxime (UNII: 0502PUN0GT) (milbemycin oxime - UNII:0502PUN0GT), lufenuron (UNII: 1R754M4918) (lufenuron - UNII:1R754M4918)

Available from:

Merck Sharp & Dohme Corp.

Administration route:

ORAL

Prescription type:

PRESCRIPTION

Therapeutic indications:

SENTINEL FLAVOR TABS are indicated for use in dogs and puppies, four weeks of age and older, and two pounds body weight or greater. SENTINEL FLAVOR TABS are also indicated for the prevention of heartworm disease caused by Dirofilaria immitis, for the prevention and control of flea populations, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxascaris leonina (roundworm) and Trichuris vulpis (whipworm) infections. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. Concurrent use of an adulticide product may be necessary for adequate control of adult fleas. Without concurrent use of an adulticide, adequate flea control may not be achieved in dogs that have repeated exposure to flea infested animals or environments.

Product summary:

SENTINEL FLAVOR TABS are available in four tablet sizes (see Dosage section) formulated according to the weight of the dog. Each tablet size is available in color-coded packages of 6 or 12 tablets each, which are packaged 10 per display carton. Store in a dry place at controlled room temperature, between 59° and 77°F (15-25°C).

Authorization status:

New Animal Drug Application

Summary of Product characteristics

SENTINEL FLAVOR TABS- MILBEMYCIN OXIME AND LUFENURON TABLET, CHEWABLE
MERCK SHARP & DOHME CORP.
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SENTINEL FLAVOR TABS
(MILBEMYCIN OXIME+LUFENURON)
The palatable once-a-month prescription tablet that prevents heartworm
disease and
flea populations in dogs and puppies. SENTINEL
FLAVOR TABS (milbemycin
oxime/lufenuron) also control flea populations and adult hookworms,
and remove and
control adult roundworm and whipworm infections in dogs and puppies.
CAUTION
Federal (USA) law restricts this drug to use by or on the order of a
licensed veterinarian.
WARNINGS
Not for human use. Keep this and all drugs out of the reach of
children.
DESCRIPTION
SENTINEL FLAVOR TABS are available in four tablet sizes in color-coded
packages for
oral administration to dogs and puppies according to their weight.
(See Dosage Section).
Each tablet is formulated to provide a minimum of 0.23 mg/pound (0.5
mg/kg) of
milbemycin oxime and 4.55 mg/pound (10 mg/kg) body weight of
lufenuron.
Milbemycin oxime consists of the oxime derivatives of
5-didehydromilbemycins in the
ratio of approximately 80% A (C
H
NO , MW 555.71) and 20% A (C
H
NO , MW
541.68). Milbemycin oxime is classified as a macrocyclic anthelmintic.
Lufenuron is a benzoylphenylurea derivative with the following
chemical composition: N-
[2,5-dichloro-4-(1,1,2,3,3,3,-hexafluoropropoxy)-phenylaminocarbonyl]-2,6-
difluorobenzamide (C
H Cl
F N O , MW 511.15). Benzoylphenylurea compounds,
including lufenuron, are classified as insect development inhibitors
(IDIs).
MODE OF ACTION
Milbemycin oxime, one active ingredient in SENTINEL FLAVOR TABS, is a
macrocyclic
anthelmintic which is believed to act by interfering with invertebrate
neurotransmission.
Milbemycin oxime eliminates the tissue stage of heartworm larvae and
the adult stage of
hookworm (_Ancylostoma caninum_), roundworm (_Toxocara canis_ and
_Toxascaris leonina_)
and whipworm (_Trichuris vulpis_) infestations when administered
orally according to the
recommended dosage schedule.
Lufenuron, the other active ingredient in S