Pays: États-Unis
Langue: anglais
Source: NLM (National Library of Medicine)
altrenogest (UNII: 2U0X0JA2NB) (altrenogest - UNII:2U0X0JA2NB)
Merck Sharp & Dohme Corp.
altrenogest
altrenogest 2.2 mg in 1 mL
ORAL
PRESCRIPTION
INDICATIONS: For suppression of estrus in mares. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Suppression of estrus will also facilitate management of prolonged estrus conditions. Suppression of estrus may be used to facilitate scheduled breeding during the physiological breeding season. CONTRAINDICATIONS: Do not use Regu-Mate® (altrenogest) in mares having a previous or current history of uterine inflammation (e.g., acute, subacute, or chronic endometritis). Natural or synthetic gestagen therapy may exacerbate existing low-grade or "smoldering" uterine inflammation into a fulminating uterine infection in some instances.
HOW SUPPLIED: Regu-Mate® (altrenogest) contains 2.2 mg/mL in an oil solution. Product supplied in 1,000 mL plastic bottles. Regu-Mate® Equine Dosing Device supplied separately.
New Animal Drug Application
REGUMATE- ALTRENOGEST SOLUTION MERCK SHARP & DOHME CORP. ---------- REGU-MATE (ALTRENOGEST) 2.2 mg altrenogest per mL (0.22%) Oral Solution for Horses CAUTION: FEDERAL LAW RESTRICTS THIS DRUG TO USE BY OR ON THE ORDER OF A LICENSED VETERINARIAN. DESCRIPTION: Regu-Mate (altrenogest) contains the active synthetic progestin, altrenogest. The chemical name is 17a-allyl-17b-hydroxyestra-4,9,11-trien-3-one. The CAS Registry Number is 850-52-2. The chemical structure is: Each mL of Regu-Mate (altrenogest) contains 2.2 mg of altrenogest in an oil solution. Regu-Mate (altrenogest) produces a progestational effect in mares. INDICATIONS: For suppression of estrus in mares. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. This facilitates the attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Suppression of estrus will also facilitate management of prolonged estrus conditions. Suppression of estrus may be used to facilitate scheduled breeding during the physiological breeding season. DOSAGE AND ADMINISTRATION: Administer solution orally at the rate of 1 mL per 110 pounds body weight (0.044 mg/kg) once daily for 15 consecutive days. Administer solution directly on the base of the mare's tongue or on the mare's usual grain ration. DOSAGE CHART APPROXIMATE WEIGHT DOSE IN ® ® ® ® (POUNDS) ML 770 7 880 8 990 9 1100 10 1210 11 1320 12 When handling Regu-Mate product, the dosing device, or syringes, ALWAYS USE VINYL, NEOPRENE, OR NITRILE GLOVES. LATEX GLOVES ARE NOT PROTECTIVE. The product may be dosed using Regu-Mate Equine Dosing Device or a luer lock syringe. Use of the Regu-Mate Equine Dosing Device is recommended to reduce the risk of human exposure. Follow all instructions when using the dosing device. DO NOT USE ANY DOSING DEVICE OTHER THAN THE REGU-MATE EQUINE DOSING DEVICE. FOR USE WITH REGU-MATE EQUINE DOSING DEVICE, first assemble the device according to directions supplied with the Regu-Mate Equine Dosing Devi Lire le document complet