UTIX Effervescent Granules

Maa: Malesia

Kieli: englanti

Lähde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiivinen ainesosa:

Citric acid anhydrous; Sodium Bicarbonate; Sodium Citrate Anhydrous; Tartaric Acid

Saatavilla:

Noripharma Sdn. Bhd.

INN (Kansainvälinen yleisnimi):

Citric acid anhydrous; Sodium Bicarbonate; Sodium Citrate Anhydrous; Tartaric Acid

Kpl paketissa:

12sachet Sachets; 28sachet Sachets

Valmistaja:

Noripharma Sdn. Bhd.

Valmisteyhteenveto

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UTIX Effervescent Granules
Each 4g sachet contains:
Sodium bicarbonate
1760 mg
Tartaric acid
890 mg
Citric acid anhydrous
720 mg
Sodium citrate anhydrous 630 mg
Also contains lime flavour.
DESCRIPTION:
Appearance of powder: White to off white granular powder with odour of
lime flavor
Appearance of solution: Clear to slight haze solution with odour of
lime flavour
PHARMACODYNAMICS:
Sodium bicarbonate acts as urinary alkaliser by increasing the
excretion of free bicarbonate ions in the
urine, thus effectively raising the urinary pH. By maintaining alkali
urine, the actual dissolution of uric acid
stones may be accomplished.
Sodium Citrate and Citric Acid:
A rise in urinary pH increased the solubility of cysteine in the urine
and the ionization of uric acids to more
soluble urate ion. By maintaining alkaline urine, the actual
dissolution of uric acid stones may be
accomplished.
Tartaric acid in combination with bicarbonates acts as the acid
component of effervescent granules.
PHARMACOKINETICS:
Sodium citrate is metabolized to bicarbonates, which increases urinary
pH by increasing the excretions of
free bicarbonate ions, without producing systemic alkalosis when
administered in recommended doses.
Sodium bicarbonate is excreted through renal and also via lung by
forming CO
2
. Sodium citrate, citric acid
and absorbed tartaric acid are excreted through urine.
INDICATIONS:
Indicated for relieving of discomfort in mild UTI; symptomatic relief
of dysuria; to enhance the action of
certain antibiotics, especially some sulphonamides; in gout therapy as
urinary alkalinisers to prevent
crystallization of urates.
DOSAGE AND ADMINISTRATION:
4g to 8g (1 to 2 sachets) dissolved in cold water four times daily for
5 days or as directed by the physician.
ROUTE OF ADMINISTRATION: Oral administration
CONTRAINDICATIONS:

Renal failure or hypernatremia

Hexamine mandelate or hexamine hippurate therapy

Caution is advised in overt and occult cardiac failure

Concomitant use of urinary alkalinisers and quinolone ant