Страна: Малайзия
Език: английски
Източник: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Citric acid anhydrous; Sodium Bicarbonate; Sodium Citrate Anhydrous; Tartaric Acid
Noripharma Sdn. Bhd.
Citric acid anhydrous; Sodium Bicarbonate; Sodium Citrate Anhydrous; Tartaric Acid
12sachet Sachets; 28sachet Sachets
Noripharma Sdn. Bhd.
Page 1 of 2 UTIX Effervescent Granules Each 4g sachet contains: Sodium bicarbonate 1760 mg Tartaric acid 890 mg Citric acid anhydrous 720 mg Sodium citrate anhydrous 630 mg Also contains lime flavour. DESCRIPTION: Appearance of powder: White to off white granular powder with odour of lime flavor Appearance of solution: Clear to slight haze solution with odour of lime flavour PHARMACODYNAMICS: Sodium bicarbonate acts as urinary alkaliser by increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining alkali urine, the actual dissolution of uric acid stones may be accomplished. Sodium Citrate and Citric Acid: A rise in urinary pH increased the solubility of cysteine in the urine and the ionization of uric acids to more soluble urate ion. By maintaining alkaline urine, the actual dissolution of uric acid stones may be accomplished. Tartaric acid in combination with bicarbonates acts as the acid component of effervescent granules. PHARMACOKINETICS: Sodium citrate is metabolized to bicarbonates, which increases urinary pH by increasing the excretions of free bicarbonate ions, without producing systemic alkalosis when administered in recommended doses. Sodium bicarbonate is excreted through renal and also via lung by forming CO 2 . Sodium citrate, citric acid and absorbed tartaric acid are excreted through urine. INDICATIONS: Indicated for relieving of discomfort in mild UTI; symptomatic relief of dysuria; to enhance the action of certain antibiotics, especially some sulphonamides; in gout therapy as urinary alkalinisers to prevent crystallization of urates. DOSAGE AND ADMINISTRATION: 4g to 8g (1 to 2 sachets) dissolved in cold water four times daily for 5 days or as directed by the physician. ROUTE OF ADMINISTRATION: Oral administration CONTRAINDICATIONS: Renal failure or hypernatremia Hexamine mandelate or hexamine hippurate therapy Caution is advised in overt and occult cardiac failure Concomitant use of urinary alkalinisers and quinolone ant Прочетете целия документ