Riik: Austraalia
keel: inglise
Allikas: Department of Health (Therapeutic Goods Administration)
Escitalopram oxalate
Lupin Australia Pty Limited
Medicine Registered
ESCITALOPRAM-LUPIN TABLETS (LUPIN AUSTRALIA PTY. LTD) NAME OF THE MEDICINE Escitalopram-Lupin Tablets 5 mg containing escitalopram (as oxalate) 5 mg, Escitalopram-Lupin Tablets 10 mg containing escitalopram (as oxalate) 10 mg, Escitalopram-Lupin Tablets 15 mg containing escitalopram (as oxalate) 15 mg and Escitalopram-Lupin Tablets 20 mg containing escitalopram (as oxalate) 20 mg ESCITALOPRAM OXALATE It is described chemically as S (+)-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroiso benzofuran-5-carbonitrile hydrogen oxalate. Escitalopram is the active enantiomer (S-enantiomer) of citalopram. Molecular formula: C 20 H 21 FN 2 O, C 2 H 2 O 4 Molecular Weight: 414.42 CAS: 219861-08-2 Chemical structure: DESCRIPTION Escitalopram oxalate is a fine white to yellow, crystalline material. Escitalopram oxalate is sparingly soluble in water, slightly soluble in acetone, soluble in ethanol and freely soluble in methanol. No polymorphic forms have been detected. EXCIPIENTS Microcrystalline cellulose, Croscarmellose sodium, , Colloidal silicon dioxide, Purified talc, Magnesium stearate and Opadry White Y-1-7000, ARTG no. 2731 (contains Hypromellose, Macrogol 400 and Titanium dioxide). _Escitalopram-Lupin tablet _ _Product Information _ _Lupin Australia Pty Ltd _ Page 2 of 39 PHARMACOLOGY PHARMACODYNAMICS: Biochemical and behavioural studies have shown that escitalopram is a potent inhibitor of serotonin (5-HT)-uptake (_in vitro _IC 50 2nM). The anti-depressant action of escitalopram is presumably linked to the potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibitory effect on the reuptake of 5- HT from the synaptic cleft. Escitalopram is a highly selective Serotonin Reuptake Inhibitor Lugege kogu dokumenti