Trifer Drops 50mg/ml

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

Iron (III) Hydroxide polymaltose complex

Available from:

UNIMED SDN BHD

INN (International Name):

Iron (III) Hydroxide polymaltose complex

Units in package:

15ml00 mL

Manufactured by:

Apex Laboratories Limited

Summary of Product characteristics

TRIFER DROPS 50MG/ML
_ _
_DESCRIPTION AND COMPOSITION: _
Brownish black coloured chocolate flavoured syrup with sweet taste and
pleasant odour.
Each ml contains:
Iron
(III)
hydroxide
polymaltose
complex
160mg
is
equivalent
to
elemental
Iron
50.00mg; in a flavoured syrupy base.
_PHARMACODYNAMICS: _
The Iron (III) hydroxide polymaltose complex (IPC) is a water –
soluble iron oxider,
macromolecular complex of polynuclear iron (III) hydroxide and
partially hydrolyzed
dextrin
(polymaltose).
The
polynuclear
iron
(III)
hydroxide
cores
are
superficially
surrounded by a number of non-covalently bound polymaltose molecules
resulting in an
overall complex molecular mass of approximately 52,300 Daltons. This
molecule is so
large that diffusion through the membrane of the mucosa is about 40
times smaller than
the one for the hexaquo-iron (II) unity. The complex is stable and
does not cause release
of ionic iron under physiological conditions. The iron in the
polynuclear “cores” is bound
in a similar structure as in the case of physiologically occurring
ferritin. Due to these
chemical and pharmacological properties, IPC is suitable for oral iron
substitution. Iron
polymaltose complex is a polysaccharide-iron complex, which is novel
iron prepration
used in the treatment of Iron deficiency anaemia. Iron, an essential
constituent of the
body, is necessary for haemoglobin formation and for the oxidative
process of living
tissue. Trifer drops is rapidly absorbed with a high rate of iron
utilization and produces as
effective increase in haemoglobin.
Trifer drops does not irritate gastric mucosa. It has palatable taste.
Trigger a shift rise in
haemoglobin. No interaction with food or medicines. Free from radical
formation. Safest
among all iron preparations. Does not cause teeth staining.
_ _
_PHARMACOKINETICS: _
The absorption of ferric iron from iron polymaltose complex (IPC) is
controlled by a feed
back mechanism. When IPC comes into contact with the Iron binding
sites at the surface
of the mucosal cells, a physicological ex