RABBIT HAEMORRHAGIC DISEASE VIRUS (LYOPHILISED)

Australia - English - APVMA (Australian Pesticides and Veterinary Medicines Authority)

Active ingredient:
RABBIT HAEMORRHAGIC DISEASE VIRUS
Available from:
NSW DEPARTMENT OF PRIMARY INDUSTRIES
INN (International Name):
RHDV (calicivirus)(3000ID50/mL)
Pharmaceutical form:
WETTABLE POWDER
Composition:
RABBIT HAEMORRHAGIC DISEASE VIRUS BIOLOGICAL-VIRUS Active 3000.0 LD50/mL
Units in package:
# 3000; # ID units
Class:
A - Agricultural
Therapeutic group:
PREPARATION OF BAITS
Therapeutic area:
VERTEBRATE POISON
Therapeutic indications:
EUROPEAN RABBIT
Product summary:
Poison schedule: 0; Withholding period: WHP: N/A.; Host/pest details: PREPARATION OF BAITS: [EUROPEAN RABBIT]; Poison schedule: 0; Withholding period: ; Host/pest details: PREPARATION OF BAITS: [EUROPEAN RABBIT]; This product is to be used only to treat grain or carrots for the preparation of baits or for the infection of wild European rabbits by direct injection in accordance with the directions of the appropriate state or territory government authority.RESTRICTED CHEMICAL PRODUCT- ONLY TO BE SUPPLIED TO OR USED BY AN AUTHORISED PERSON.
Authorization status:
Registered
Authorization number:
50675
Authorization date:
2019-07-01

----------------------

Draft

Bottle,

Virus

Label

Lyophilised

Rabbit

Haemorrhagic Disease Virus

(for reconstitution)

,---------------------------------A~~~)

proved

RABBIT HAEMORRHAGIC

DISEASE VIRUS

(L

YOPHILISED)

Contains:

RABBIT

HAEMORRHAGIC

DISEASE

VIRUS

(CAPM

V-351) 3000

IDso

UNITS

For the infection

of

European rabbits

Net Contents: 3000 units

Lyophillised Rabbit Haemorrhagic Disease Virus (RHDV)

Directions for use:

READ ENCLOSED LEAFLET BEFORE USING THIS PRODUCT. Strictly

administration

European rabbits. For disposal

containers, refer

the leaflet.

Department

Primary Industries, Elizabeth McArthur Agricultural Institute

Woodbridge Road, Menangle,

2568

APVMA

50675/62269

Store

below

-5°C

(freeze)

Batch

Date

Manufacture

Draft Leaflet for Lyophilised Rabbit Haemorrhagic Disease Virus (for reconstitution)

READ SAFETY DIRECTIONS BEFORE OPENING

OR

USING

RABBIT HAEMORRHAGIC

DISEASE VIRUS (L YOPHILISED)

Active constituent: RABBIT HAEMORRHAGIC DISEASE VIRUS (CAPM V-351) 3000

IDso

UNITS

For the infection of wild European rabbits

in

accordance with

directions of the appropriate State or Territory government authority.

RESTRICTED CHEMICAL

PRODUCT-ONLY

TO BE SUPPLIED TO

OR USED BY AN AUTHOURISED PERSON.

Net Contents:

3000 units of lyophillised Rabbit Haemorrhagic Disease Virus (RHDV) per

vial

Store Below -5°C (freeze)

APVMA Approval Number: 50675162269

Batch No.:

DOM:

Expiry Date:

Address: NSW Department

Primary Industries, Elizabeth McArthur Agricultural Institute

Woodbridge Road, Menangle, NSW 2568

Rabbit haemorrhagic disease virus (RHDV) is highly

infectious

usually fatal pathogen that causes

acute clinical symptoms resulting

death only

European rabbits

Oryctolagus cuniculus.

All breeds

of rabbits

Australia are derived from the

Oryctolagus cuniculus

and are therefore potentially

susceptible

infection with RHDV.

A vaccine

protect pet and farmed rabbits from RHDV

available from your local veterinarian.

Once a rabbit

infected, the virus replicates rapidly within the liver.

The rabbit usually dies within three days

infection

survive longer and may recover. While

young rabbits (less than 8 weeks old) often fail to

succumb to RHDV, older rabbits are highly

susceptible.

DIRECTIONS

FOR

USE

RESTRAINTS:

DO NOT administer to any animal other than wild

European rabbits.

DO NOT administer to rabbits visibly affected by

myxomatosis. Rabbits affected by active myxoma

virus infection may be less likely

die as a result

Rabbit haemorrhagic disease (RHD).

DO NOT administer to rabbits younger than 12

weeks. Younger rabbits

be infected with rabbit

haemorrhagic (RHDV) but are less likely to die as a

result

RHDV, particularly

the presence

maternal antibodies.

RHDV may

administered

susceptible rabbits either by direct injection or by

means of infected carrot or oat feed.

Administration

by

intramuscular injection:

Capture at least two wild rabbits from each warren.

Using a sterile syringe, reconstitute the lyophilized

virus by adding 10ml of sterile distilled water and

swirl gently for a

minutes. Using a sterile syringe,

remove a 0.5

dose of virus suspension from the

vial.

Inject

each recipient rabbit at an intramuscular

(1M)

site

the hind leg with

0.5ml

of reconstituted

virus suspension and release the rabbits back into

the warren from which they were captured.

It is recommended that rabbits

captured and re-

released into the same warren to maximise the

likelihood

acceptance of the infected rabbit by its

cohorts.

A minimum of

rabbits should be injected at each

release site but preferably up to 20 rabbits should be

treated.

Administration

by

medicated

feed:

RHDV

administered

susceptible rabbits via

the oral route on either oats

chopped carrots.

Oats should be standard intact oats with husks

attached.

Carrots should be freshly diced.

RHDV

treated

oats

must be applied in trails but

RHDV

treated chopped carrot

applied

trails

broadcast.

Free feed the area

broadcast

trail with untreated oats

chopped

carrots at a

rate appropriate to the local rabbit density. Typically

rate will

the range

2-5 Kg

trail

oats and 5-10

trail

carrots.

Free

feeds should

given on

least two and,

oats,

on preferably three occasions to train rabbits to

accept

the feed.

Prepare the

RHDV

treated oats

carrots by first

reconstituting lyophilized virus using

distilled

water and then diluting a reconstituted vial

virus to

a final volume

OOmL

with distilled water (i.e. add

the contents

L vial to 90

water).

diluted suspension

carrots

oats

while

tumbling in an enclosed mixing device (as per the

minimum standard requirement

1080

bait mixing),

and continue

until the

suspension

is evenly

distributed

amongst

the feed.

RATES

OF

APPLICATION

OF

RCV

TO

FEED

recommended

dose rates

RHDV

the feed

are as follows:

vial

reconstituted product (1Om!) diluted with

an additional

water

OOml

total volume) is

sufficient to treat 5 Kg

oats

1 0 Kg

chopped

carrots.

. Treated oats

carrots should

offered to rabbits

number

warrens

area

in which it is desired

induce an outbreak

by adequate

deployment

trails

broadcast baiting.

medicated feed should

used

soon

possible

after

preparation. It should

laid in the

evening and bait

consumed

the following

morning should be recovered and destroyed.

NOT

TO

BE

USED

FOR

ANY PURPOSE, OR

IN

ANY MANNER, CONTRARY TO THIS

LABEL

UNLESS AUTHORIZED UNDER APPROPRIATE

LEGISLATION.

NOTE:

RHDV

has the potential

spread

rapidly

from individual infected rabbits to cohorts within the

same

warren and to

warrens in

same

area

some

distance (up to many kilometres)

away

from

initial site

infection.

However,

rate

movement

and proportion

warrens affected is

highly variable.

Since the factors which control the

rate

spread

fully understood,

guarantee

can be given that the virus will spread from an

infected rabbit to

other

rabbits.

PROTECTION

OF

NATIVE ANIMALS:

Decline

rabbit

numbers

from

cause

result

in increased predation on critical populations

vulnerable

endangered native animals,

least in

the short term. If the existence

a critical population

is suspected in

area

deliberate release

RCD, advice should be

sought

from

State

Territory

conservation agencies

that appropriate

predator

control measures

implemented

necessary.

PROTECTION

OF

CROPS

AND

LIVESTOCK

apply

treated bait

crops

situations

where

livestock

have

access to

bait.

STORAGE

AND

DISPOSAL:

STORE

VIRUS

BELOW

-5°C

(FREEZE)

ENTIRE

CONTENTS

VIAL

WITHIN

HOURS

INITIAL

OPENING.

STORE

OPEN

VIAL

4°C, DO

RE-FREEZE.

needles/sharps should immediately be placed in

a designated and appropriately labeled 'sharps'

container. Open and used vials, and used

needles

and syringes, should

left in

open

environment,

other

places

where

unintended

contact is possible.

Used vials and syringes should

soaked

0.5% sodium hypochlorite (e.g. a 1 in

20 dilution in

water

household bleach solution

containing

sodium hypochlorite) and buried in a

local authority landfill.

a local authority landfill is

available, bury the containers

below

500mm

in a

disposal pit specifically marked and

this

purpose clear

waterways, vegetation and roots.

Unused baits should also be buried in this

manner.

Empty

containers and products should

burnt.

Equipment used

prepare the medicated

feed

should be decontaminated and cleaned at

each

rinsing with

0.5%

sodium hypochlorite.

Following this treatment, wash thoroughly with

excess

water

allow

equipment

to dry.

SAFETY DIRECTIONS:

RHDV

affects

only

European rabbits

Oryctolagus

cuniculus.

However,

presence

rabbit

and viral proteins in

product, it is possible that

accidental administration

the product

a user,

could be

accompanied

adverse allergic

reaction.

When

mixing the virus in oats

carrots, it

is advisable to wear water-impermeable gloves and a

full

face

mask

to reduce the opportunity for

foreign protein

contact skin, eyes,

mucous

membranes.

Thoroughly

wash exposed skin with

soapy

water

after

preparing medicated feed.

If an

adverse reaction occurs,

seek

medical advice

FIRST

AID:

If poisoning occurs contact a doctor or

Poisons

Information Centre

(Phone

131126)

Additional information is listed in

Material

Safety

Data

Sheet

CONDITIONS OF SALE:

The Elizabeth McArthur Agricultural Institute,

w South Wales Department

Primary Industries will

not accept responsibility for losses or damage arising from the supply

these goods other than

the responsibility for the merchantable quality

the goods.

the extent allowed by the relevant laws

in each State, the liability

the Department

imary Industries is limited to the replacement of goods

in the event that a valid claim of deficiencies in merchantable quality is proven.

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