PEG-INTRON CLEARCLICK FOR INJECTION 120 mcg/0.5 ml
Country: Singapore
Language: English
Source: HSA (Health Sciences Authority)
Patient Information leaflet
(PIL)
05-12-2014
Some documents for this product are not currently available, you can send a request to our customer service and we will notify you as soon as we are able to obtain them.
Send request.
Send request.
Active ingredient:
PEGINTERFERON ALFA-2B
Available from:
MSD PHARMA (SINGAPORE) PTE. LTD.
ATC code:
L03AB10
Dosage:
120 mcg/0.5 ml
Pharmaceutical form:
INJECTION, POWDER, FOR SOLUTION
Administration route:
SUBCUTANEOUS
Prescription type:
Prescription Only
Manufactured by:
MSD INTERNATIONAL GMBH (SINGAPORE BRANCH)
Authorization date:
2003-08-29
Patient Information leaflet
S-CCDS-MK4031-ALL-072013
Peg-Intron® CLEARCLICK Pre-filled Pen Powder and Solvent for Solution
for Injection
Brand of peginterferon alfa-2b
FOR SUBCUTANEOUS ADMINISTRATION
DESCRIPTION: Peg-Intron CLEARCLICK Pre-filled Pen is a
single dose presentation available in
strengths of 50 mcg, 80 mcg, 100 mcg, 120 mcg, and 150 mcg
powder and solvent for solution for
injection in pre-filled pens.
Peginterferon alfa-2b is a conjugation of recombinant interferon
alfa-2b with monomethoxy
polyethylene glycol. When reconstituted with solvent , each Peg-Intron CLEARCLICK Pre-filled Pen
provides 0.5 ml of solution containing
either 50 mcg, 80 mcg, 100 mcg, 120 mcg or 150 mcg.
Peg-Intron CLEARCLICK Pre-filled Pen
also contains as excipients anhydrous disodium phosphate,
dihydrate sodium dihydrogen phosphate, sucrose and polysorbate 80. The solvent provided for
parenteral use is sterile water for injection.
The deliverable volume from
each Peg-Intron CLEARCLICK Pre-filled Pen
is 0.5 ml. An overfill is
included for proper dispensing from the pen delivery system.
ACTIONS:
In vitro
and
in vivo
studies suggest that the biological activity of peginterferon alfa-2b is
derived from its interferon alfa-2b moiety.
Interferons exert their cellular activities by binding to
specific membrane receptors on the cell surface.
Studies with other interferons have demonstrated species specificity. However, certain monkey
species, e.g., Rhesus monkeys, are susceptible to
pharmacodynamic stimulation upon exposure to
human type 1 interferons.
Once bound to the cell membrane, interferon initiates a
complex sequence of intracellular events that
include the
induction of certain enzymes. It is thought that this process, at least in
part, is responsible
for the various cellular responses to int
Read the complete document
