Country: Malaysia
Language: English
Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
MADURAMICIN AMMONIUM
Weissen Company (m) Sdn. Bhd.
MADURAMICIN AMMONIUM
25.00 mcg/mL
Zhejiang Apeloa Kangyu Bio-Pharmaceutical Co.,Ltd
PACKAGE I N SE R T Maduramicin Ammonium Premix 1% Brand or product Name Maduramicin Ammonium Premix 1% Powder Name and strength of active substance(s) Maduramicin ammonium 1% Product Description Pale yellow to russet brown powder or granule Pharmacodynamics Maduramicin is a monovalent glycoside polyether ionophore antibiotic. It induces an anticoccidial effect on the asexual forms (sporozoites, merozoites and falciform bodies) of the endogenous development of coccidia in poultry, some resistant forms to other ionophore antibiotics included. Its anticoccidial activity is due to disorder in ion metabolism (potassium and sodium in particular). Pharmacokinetics Maduramicin was excreted rapidly in chickens. Steady state was observed after three days in the excreta, but after six days in plasma. Maduramicin was the main compound excreted (26 %). Odemethylation represented the main metabolic pathway of maduramicin common to chickens and rats. Liver is the target tissue; maduramicin is the marker residue in all tissues tested. Tissue residue kinetics of total residues and marker residue indicate a rapid decline of residues in all tissues. Ratios maduramicin to total residues have been established. Environmental Properties Not Applicable Indication As an aid in the prevention of coccidiosis caused by Eimeria necatrix , E. tenella , E. acervulina , E. brunetti , E. maxima and E. mivati . Recommended Dosage Thoroughly mix the product into the feed at a level of 500gm per tonne of broiler feed to obtain a concentration of 5g/t maduramicin ammonium in the complete feed. Feed containing the product should be the only ration fed to broilers to avoid dilution of the active ingredient. Mode of Administration Oral route, by mixing the product with feeding stuff Contraindication None. Warning and precaution For use in feeds intended for chicken only. Do not mix with or use simultaneously with feed containing another anticoccidial. Direct contact with the skin is to be avoided. When mixing and handling this product, use protective c Read the complete document