CORIFED TABLET

Country: Malaysia

Language: English

Source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Active ingredient:

PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE

Available from:

PAHANG PHARMACY SDN. BHD.

INN (International Name):

PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE

Units in package:

10tablet Tablets; 20tablet Tablets; 30tablet Tablets; 50tablet Tablets; 100tablet Tablets; 250tablet Tablets; 500tablet Tablets; 1000tablet Tablets

Manufactured by:

Noripharma Sdn. Bhd.

Patient Information leaflet

CORIFED TABLET _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
TRIPROLIDINE HYDROCHLORIDE 2.5MG/PSEUDOEPHEDRINE HYDROCHLORIDE 60MG
IN THIS LEAFLET
:
1.
What is CORIFED used for
2.
How does CORIFED works
3.
Before you take CORIFED
4.
How to take CORIFED
5.
While using CORIFED
6.
Side effects
7.
How to store and dispose
CORIFED
8.
Product description
9.
Manufacturer
10.
Date of Revision
1.
WHAT IS CORIFED USE FOR
This medicine is used to relieve the
symptoms of colds, flu and allergies
including runny nose, watery eyes,
nasal congestion and blocked
sinuses.
2.
HOW CORIFED WORKS
The tablets contain pseudoephedrine
hydrochloride which is a decongestant
that shrinks swollen nasal mucous
membrane, reduces nasal hyperemia,
relieves nasal, edema and sinus
congestion and increase nasal airway
potency. Triprolidine hydrochloride is
an antihistamine that that reduces the
natural chemical histamine in the body
and helps to stop sneezy, runny nose
and watery eyes. It also has
anticholinergic actions and provide a
drying effect on the nasal mucosa.
3.
BEFORE YOU TAKE CORIFED
_When you must not take it_
•
If you have very high blood
pressure or severe heart
disease.
•
If you have ever had a bad
reaction to any of the
ingredients.
•
If you are taking, or have taken
in the last two weeks, drugs for
depression known as
Monoamine Oxidase Inhibitor
(MAOIs) such as isocarboxazid,
phenelzine rasagiline, selegiline
or tranylcypromine
_ _
_Before you start to take it._
Inform your doctor if you
have
•
liver or kidney problems.
•
high blood pressure or heart
disease.
•
diabetes or if you been told by
your doctor that you have an
intolerance to some sugars.
•
an overactive thyroid gland.
•
glaucoma (increased pressure in
the eye).
•
prostate problems (difficulty
with passing water or needing
to pass water often).
•
taking alcohol.
•
pregnant or plan to become
pregnant during treatment
•
breast-feeding a baby.
_ _
_Taking other medicines _
Please tell your doctor or pharmacist if
you are taking or have recently ta

Summary of Product characteristics

1
CORIFED TABLET
COMPOSITION:
Each tablet contains:
Triprolidine Hydrochloride
2.5mg
Pseudoephedrine Hydrochloride
60mg
DESCRIPTION:
A yellow round shaped tablet with score line on one side.
PHARMACODYNAMICS:
Pseudoephedrine is an orally effective upper respiratory tract
decongestant. It acts on alpha-
adrenergic receptors in the mucosa of the respiratory tract, producing
vasoconstriction. It
shrinks swollen nasal mucous membrane; reduces tissue hyperemia, edema
and nasal
congestion; and increases nasal airway potency. Drainage of sinus
secretions may be increased
and obstructed eustachian ostia may be opened.
Triprolidine is an antihistamine (H1-receptor). It acts by competing
with histamine for H1-
receptor sites on effector cells. It prevents, but does not reverse,
responses mediated by
histamine alone. It also has anticholinergic actions and provides a
drying effect on the nasal
mucosa.
PHARMACOKINETICS:
Pseudoephedrine is almost completely and rapidly absorbed from the
G.I.T. Pseudoephedrine is
incompletely metabolised in the liver. Onset of action is within 15 to
30 minutes and has a
duration of action for 3 to 4 hours. Elimination is renal and about
75% is excreted unchanged.
The rate of excretion is accelerated in acidic urine.
Triprolidine is absorbed from the G.I.T. The time to peak effect is 2
to 3 hours, half life of 3 to 3.3
hours and a duration of action of 4 to 8 hours. It is metabolised in
the liver and is excreted in the
urine.
INDICATION:
Corifed Tablet is indicated for the temporary relief of nasal and
sinus congestion, sneezing and
rhinorrhea associated with the common cold and allergic rhinitis.
ROUTE OF ADMINISTRATION:
Oral administration.
RECOMMENDED DOSE:
Adults and children over 12 years
: 1 tablet three times a day.
Children 6 – 12 years
: ½ tablet three times a day.
CONTRAINDICATION:
Contraindicated in patients with a known hypersensitivity to
pseudoephedrine or triprolidine.
Also contraindicated in patients under treatment with monoamine
oxidase inhibitors or within
two weeks of sto