CHORULON- gonadotrophin, chorionic kit

Country: United States

Language: English

Source: NLM (National Library of Medicine)

Active ingredient:

CHORIONIC GONADOTROPIN (UNII: 20ED16GHEB) (CHORIONIC GONADOTROPIN - UNII:20ED16GHEB)

Available from:

Merck Sharp & Dohme Corp.

INN (International Name):

Gonadotrophin, Chorionic

Composition:

Gonadotrophin, Chorionic 10000 [iU]

Prescription type:

PRESCRIPTION

Therapeutic indications:

INDICATIONS COWS: CHORULON® is indicated for intramuscular use in cows for the treatment of nymphomania (frequent or constant heat) due to cystic ovaries. FINFISH: CHORULON® is indicated for use as an aid in improving spawning function in male and female brood finfish.

Product summary:

HOW SUPPLIED CHORULON® is supplied in cartons containing five vials of freeze-dried powder and five 10 mL vials of sterile diluent. order Code No. CH-475-1.

Authorization status:

New Animal Drug Application

Summary of Product characteristics

CHORULON- GONADOTROPHIN, CHORIONIC
MERCK SHARP & DOHME CORP.
----------
CHORULON
Approved by FDA under NADA # 140-927
FOR ANIMAL USE ONLY
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
CHORULON is a freeze-dried preparation of chorionic gonadotropin
(human Chorionic
Gonadotropin or hCG) for intramuscular administration after
reconstitution. When
reconstituted with the accompanying sterile diluent, each 10 mL vial
contains 10,000 I.U.
chorionic gonadotropin (equivalent to 10,000 USP Units chorionic
gonadotropin) and 10
mg mannitol, with mono- and disodium phosphate to adjust the pH of the
solution.
ACTION
Chorionic gonadotropin has luteinizing hormone-like activity with
little or no follicle
stimulating or estrogenic activity.
INDICATIONS
COWS: CHORULON is indicated for intramuscular use in cows for the
treatment of
nymphomania (frequent or constant heat) due to cystic ovaries.
FINFISH: CHORULON is indicated for use as an aid in improving spawning
function in
male and female brood finfish.
DOSAGE AND ADMINISTRATION
To reconstitute, transfer the contents of one vial of sterile diluent
into one vial of freeze-
dried powder. The resulting 10 mL of CHORULON contains 10,000 I.U.
chorionic
gonadotropin.
COWS: The contents of one vial (10 mL) of reconstituted CHORULON
should be
administered as a single deep intramuscular injection. Dosage may be
repeated in 14
days if the animal's behavior or rectal examination of the ovaries
indicates the necessity
for retreatment.
FINFISH: CHORULON should be administered via intramuscular injection
just ventral to
the dorsal fin for one (1) to three (3) injections. Any single
injection should be
administered, depending on the fish species, at a dose of 50 to 510
I.U./lb body weight
(bw) for males and 67 to 1816 I.U./lb bw for females. Depending on
body weight and
dose administered, it may be necessary to divide the dose among two or
more injection
sites to avoid injecting a large volume at a single site.
Summaries of doses test