TIMOLOL TABLET

Χώρα: Καναδάς

Γλώσσα: Αγγλικά

Πηγή: Health Canada

Δραστική ουσία:

TIMOLOL MALEATE

Διαθέσιμο από:

AA PHARMA INC

Φαρμακολογική κατηγορία (ATC):

C07AA06

INN (Διεθνής Όνομα):

TIMOLOL

Δοσολογία:

10MG

Φαρμακοτεχνική μορφή:

TABLET

Σύνθεση:

TIMOLOL MALEATE 10MG

Οδός χορήγησης:

ORAL

Μονάδες σε πακέτο:

100/500

Τρόπος διάθεσης:

Prescription

Θεραπευτική περιοχή:

BETA-ADRENERGIC BLOCKING AGENTS

Περίληψη προϊόντος:

Active ingredient group (AIG) number: 0110849001; AHFS:

Καθεστώς αδειοδότησης:

APPROVED

Ημερομηνία της άδειας:

2018-02-27

Αρχείο Π.Χ.Π.

PRODUCT MONOGRAPH
TIMOLOL
TIMOLOL MALEATE TABLETS USP
TABLETS 5 MG, 10 MG AND 20 MG
ANTIHYPERTENSIVE AND ANTI-ANGINAL AGENT
AA PHARMA INC.
1165 CREDITSTONE ROAD, UNIT#1
VAUGHAN, ONTARIO
L4K 4N7
CONTROL NUMBER: 212835
DATE OF REVISION:
February 19, 2018
NAME
OF DRUG
TIMOLOL
(timolol maleate)
Tablets 5, 10 and 20 mg
THERAPEUTIC CLASSIFICATION
Antihypertensive and Anti-Anginal Agent
ACTIONS
TIMOLOL (timolol maleate) is a beta-adrenergic blocking agent.
The mechanism of the antihypertensive effect of beta adrenergic
receptor blocking agents has
not yet been established. Among the factors that may be involved are:
(i) competitive ability to antagonize catecholamine-induced
tachycardia at the beta receptor
sites in the heart, thus decreasing cardiac output,
(ii) inhibition of renin release by the kidneys,
(iii) inhibition of the vasomotor centres.
The exact mechanism by which timolol maleate exercises its
anti-anginal effect is not certain but
it may reduce the oxygen requirements of the heart by blocking
catecholamine-induced
increases in heart rate, systolic blood pressure and the velocity and
extent of myocardial
contraction. However oxygen requirements may be increased by such
actions as increases in
left ventricular fibre length, end diastolic pressure and the systolic
ejection period. When the net
physiological effect is advantageous in anginal patients it manifests
itself during exercise or
stress by delaying the onset of pain and reducing the incidence and
severity of anginal attacks.
Timolol can therefore increase the capacity for work and exercise in
such patients. In a multi-
clinic study, two-thirds of the patients treated with timolol maleate
benefited to some degree.
Timolol has been found effective in prophylactic use for secondary
prevention in patients with
ischemic heart disease who have survived the acute phase of a
myocardial infarction. At the
present time, the mechanism of this protective effect of timolol is
unknown.
Bioavailability
TIMOLOL 10 mg Tablet
The bioavailability of a single oral dose o