দেশ: কানাডা
ভাষা: ইংরেজি
সূত্র: Health Canada
TIMOLOL MALEATE
AA PHARMA INC
C07AA06
TIMOLOL
10MG
TABLET
TIMOLOL MALEATE 10MG
ORAL
100/500
Prescription
BETA-ADRENERGIC BLOCKING AGENTS
Active ingredient group (AIG) number: 0110849001; AHFS:
APPROVED
2018-02-27
PRODUCT MONOGRAPH TIMOLOL TIMOLOL MALEATE TABLETS USP TABLETS 5 MG, 10 MG AND 20 MG ANTIHYPERTENSIVE AND ANTI-ANGINAL AGENT AA PHARMA INC. 1165 CREDITSTONE ROAD, UNIT#1 VAUGHAN, ONTARIO L4K 4N7 CONTROL NUMBER: 212835 DATE OF REVISION: February 19, 2018 NAME OF DRUG TIMOLOL (timolol maleate) Tablets 5, 10 and 20 mg THERAPEUTIC CLASSIFICATION Antihypertensive and Anti-Anginal Agent ACTIONS TIMOLOL (timolol maleate) is a beta-adrenergic blocking agent. The mechanism of the antihypertensive effect of beta adrenergic receptor blocking agents has not yet been established. Among the factors that may be involved are: (i) competitive ability to antagonize catecholamine-induced tachycardia at the beta receptor sites in the heart, thus decreasing cardiac output, (ii) inhibition of renin release by the kidneys, (iii) inhibition of the vasomotor centres. The exact mechanism by which timolol maleate exercises its anti-anginal effect is not certain but it may reduce the oxygen requirements of the heart by blocking catecholamine-induced increases in heart rate, systolic blood pressure and the velocity and extent of myocardial contraction. However oxygen requirements may be increased by such actions as increases in left ventricular fibre length, end diastolic pressure and the systolic ejection period. When the net physiological effect is advantageous in anginal patients it manifests itself during exercise or stress by delaying the onset of pain and reducing the incidence and severity of anginal attacks. Timolol can therefore increase the capacity for work and exercise in such patients. In a multi- clinic study, two-thirds of the patients treated with timolol maleate benefited to some degree. Timolol has been found effective in prophylactic use for secondary prevention in patients with ischemic heart disease who have survived the acute phase of a myocardial infarction. At the present time, the mechanism of this protective effect of timolol is unknown. Bioavailability TIMOLOL 10 mg Tablet The bioavailability of a single oral dose o সম্পূর্ণ নথি পড়ুন