Land: Malaysia
Sprache: Englisch
Quelle: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
OXYTETRACYCLINE HYDROCHLORIDE
Thye Pharma Sdn. Bhd
OXYTETRACYCLINE HYDROCHLORIDE
500 gm; 1 kg
Thye Pharma Sdn. Bhd
Veterinary Package Insert TP-OTC HCL 500MG/G WATER SOLUBLE POWDER (50% Oxytetracycline Hydrochloride) PRODUCT DESCRIPTION Yellow colour powder, which contains 50% of Oxtetracycline Hydrochloride (equivalent to 46.3% of Oxytetracycline), i.e. 500mg of Oxytetracycline Hydrochloride (equivalent to 463mg of Oxytetracycline) in 1 gm. PHARMACODYNAMICS & PHARMACOKINETICS The oxytetracycline links reversibly to the ribosomal subunit 30S receptors, this leading to a blockage of the union between aminoacyl-tRNA to the site corresponding to the mRNA-ribosome complex messenger. It results in an inhibition of the protein synthesis and inhibits bacterial growth. The mainly bacteriostatic activity of oxytetracycline involves uptake of the substance into the bacterial cell which occurs by both passive and active diffusions. The main mechanism of resistance is due to the possible presence of a R factor responsible for a decrease in the active transport of oxytetracycline. Oxytetracycline is a broad-spectrum antibiotic. It is mainly active against Gram-positive and Gram negative bacteria, aerobic and anaerobic, as well as against mycoplasma, the Chlamydia and Rickettsiae. The oral absorption of oxytetracycline is low. The mean values of oral absorption of oxytetraycline are 3-5% in pigs and 48% in turkeys. This bioavailability can be reduced in the presence of food in the stomach as oxytetracycline leads to the formation of insoluble chelates with divalent or trivalent cations (Mg, Fe, Al, Ca). In pigs, the influence of food is negligible on the bioavailability of oxytetracycline which is less than 5%. The oxytetracycline binds variably to plasma proteins according to the species (75%). Its distribution is large. The oxytetracycline diffuses throughout the body, the highest concentrations have been found in the kidneys, liver, spleen and lungs. The oxytetracycline crosses the placental barrier. Oxytetracycline is excreted unchanged mainly via urine. It is also excreted via bile but a high proportion of oxytetracycline is reabsorbe Lesen Sie das vollständige Dokument