TP-OTC HCL 500MGG WATER SOLUBLE POWDER

Country: Malaysia

Bahasa: Inggeris

Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Bahan aktif:

OXYTETRACYCLINE HYDROCHLORIDE

Boleh didapati daripada:

Thye Pharma Sdn. Bhd

INN (Nama Antarabangsa):

OXYTETRACYCLINE HYDROCHLORIDE

Unit dalam pakej:

500 gm; 1 kg

Dikeluarkan oleh:

Thye Pharma Sdn. Bhd

Ciri produk

Veterinary Package Insert
TP-OTC HCL 500MG/G WATER SOLUBLE
POWDER (50% Oxytetracycline
Hydrochloride)
PRODUCT DESCRIPTION
Yellow
colour
powder,
which
contains
50%
of
Oxtetracycline Hydrochloride (equivalent to 46.3%
of Oxytetracycline), i.e. 500mg of Oxytetracycline
Hydrochloride
(equivalent
to
463mg
of
Oxytetracycline) in 1 gm.
PHARMACODYNAMICS & PHARMACOKINETICS
The oxytetracycline links reversibly to the ribosomal
subunit 30S receptors, this leading to a blockage of
the
union
between
aminoacyl-tRNA
to
the
site
corresponding
to
the
mRNA-ribosome
complex
messenger.
It results in an inhibition of the protein synthesis
and
inhibits
bacterial
growth.
The
mainly
bacteriostatic
activity
of
oxytetracycline
involves
uptake
of
the
substance
into
the
bacterial
cell
which occurs by both passive and active diffusions.
The main mechanism of resistance is due to the
possible presence of a R factor responsible for a
decrease in the active transport of oxytetracycline.
Oxytetracycline is a broad-spectrum antibiotic. It is
mainly
active
against
Gram-positive
and
Gram
negative bacteria, aerobic and anaerobic, as well
as
against
mycoplasma,
the
Chlamydia
and
Rickettsiae.
The oral absorption of oxytetracycline is low. The
mean values of oral absorption of oxytetraycline
are 3-5% in pigs and 48% in turkeys.
This bioavailability can be reduced in the presence
of food in the stomach as oxytetracycline leads to
the formation of insoluble chelates with divalent or
trivalent cations (Mg, Fe, Al, Ca).
In pigs, the influence of food is negligible on the
bioavailability of oxytetracycline which is less than
5%.
The oxytetracycline binds variably to plasma proteins
according to the species (75%). Its distribution is
large. The oxytetracycline diffuses throughout the
body, the highest concentrations have been found in
the
kidneys,
liver,
spleen
and
lungs.
The
oxytetracycline crosses the placental barrier.
Oxytetracycline is excreted unchanged mainly via
urine.
It
is
also
excreted
via
bile
but
a
high
proportion of oxytetracycline is reabsorbe