Land: Australien
Sprache: Englisch
Quelle: Department of Health (Therapeutic Goods Administration)
mirtazapine
Arrow Pharma Pty Ltd
Mirtazapine
Registered
MIRTANZA MIRTAZAPINE 1 MIRTANZA MIRTAZAPINE _Contains the active ingredient mirtazapine _ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055 _ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about mirtazapine. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is Mirtanza Mirtazapine. It contains the active ingredient mirtazapine. It is used to treat and prevent reoccurrence of depression. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. _HOW IT WORKS _ Depression is longer lasting or more severe than the "low moods" everyone has from time to time due to the stress of everyday life. It is thought to be caused by a chemical imbalance in parts of the brain. This affects your whole body and can cause emotional and physical symptoms, such as feeling low in spirit, loss of interest in activities, unable to enjoy life, poor appetite or overeating, disturbed sleep, often waking up early, loss of sex drive, lack of energy and feeling guilty over nothing. Mirtazapine corrects this che Lesen Sie das vollständige Dokument
Product Information – Australia MIRTANZA Mirtazapine Tablets Page 1 MIRTANZA MIRTAZAPINE TABLETS NAME OF THE MEDICINE Mirtazapine Chemical Name: (±)-1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benz- azepine. Structural Formula: Molecular Formula: C 17 H 19 N 3 Molecular Weight: 265.36 CAS Registry Number: 61337-67-5 DESCRIPTION Mirtazapine is a tetracyclic piperazinoazepine analogue of mianserin, a chemical structure unrelated to tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs) or selective serotonin reuptake inhibitors. Mirtazapine is a white to creamy white crystalline powder which is slightly soluble in water. Each mirtazapine tablet contains mirtazapine as the active ingredient. In addition, each tablet contains the following inactive ingredients: lactose, cellulose microcrystalline, croscarmellose sodium, magnesium stearate, hypromellose, hyprolose , macrogol 8000, titanium dioxide, iron oxide yellow CI 77492 (15 mg and 30 mg), iron oxide red CI 77491 (30 mg only). PHARMACOLOGY PHARMACOLOGICAL ACTIONS Mirtazapine is an antidepressant, which can be given as treatment for episodes of major depression. Mirtazapine is an antagonist of central α 2 -auto and hetero-adrenoceptors which causes an increase in both noradrenaline and serotonin release. The effect of released serotonin is exerted specifically via 5-HT 1 type receptors, because 5-HT 2 and 5-HT 3 type receptors are specifically blocked by mirtazapine. Mirtazapine is accordingly a noradrenergic and specific serotonergic antidepressant. The α 2 , 5-HT 2 and 5-HT 3 antagonistic effects all contribute to the antidepressant profile of mirtazapine. The presentation of mirtazapine is as a racemate. The two enantiomers contribute differently to its pharmacological profile. The α 2 and 5-HT 2 receptor blocking activity is contained in the (S)+ enantiomer, whereas the 5-HT 3 receptor blocking activity is contained in the (R)- enantiomer. The presence of both enantiomers is therefore considered to be essential for the antide Lesen Sie das vollständige Dokument