Reten Five Solution 5g100ml

Země: Malajsie

Jazyk: angličtina

Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivní složka:

MINOXIDIL

Dostupné s:

IMEKS PHARMA SDN. BHD.

INN (Mezinárodní Name):

MINOXIDIL

Jednotky v balení:

30ml1Units mL; 60 ml 1 Units mL

Výrobce:

T.O. PHARMA CO LTD

Informace pro uživatele

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
RETEN FIVE SOLUTION 5G/100ML
®
Minoxidil (5g/100ml)
_ _
1
WHAT IS IN THE LEAFLET
1.
What Reten Five is used for
2.
How Reten Five works
3.
Before you use Reten Five
4.
How to use Reten Five
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Reten Five
8.
Product Description
9.
Manufacturer and Product Registration
Holder
10.
Date of Revision
WHAT RETEN FIVE IS USED FOR
Reten Five is used in the treatment of hair
loss and baldness in adult men and some
women.
HOW RETEN FIVE
WORKS
Reten Five possible work by increasing
diameter of hair shaft, stimulate active
growth phase and enhancing
microcirculation to hair follicles. The exact
way that Reten Five work is not known.
BEFORE YOU USE RETEN FIVE_ _
-
_When you must not use it_
• You are hypersensitive to the active
ingredient or any other ingredients in the
formulation.
• You are under 18 years old or over 65 years
old.
-
_Before you start to use it _
Tell your doctor if you:
• Have any unusual or allergic reaction to
minoxidil or other ingredients in this
preparation
• Have any other skin problems, an irritation,
or a sunburn on the scalp
• Have heart problems or high blood pressure
• Have tumour of the adrenal gland
• Are using other topical preparation
• Are pregnant or nursing
• Are HIV positive
• Have kidney problems
If you are not sure whether you should start
taking this product, consult your doctor.
-
_Taking other medicines _
Tell your doctor if you are taking any other
medicine, including any that you buy without
a prescription. You may need to use different
amounts of these medicines, or you may
need to take different medicines. Your doctor
will advise you. In particular, tell your doctor
if you take any of the following:
• Blood pressure lowering medicines, e.g:
guanethidine
• Medicines used on skin, e.g: tretinoin,
anthtalin/ditranol, corticosteroids, and
occulusive ointment bases
• Paracetamol and diethylcarbamazine which
might counter minoxidil effects
-
_Pr

Charakteristika produktu

PLEASE READ CAREFULLY
TO BE SUPPLIED ONLY ON THE PRESCRIPTION OF A REGISTERED MEDICAL
PRACTITIONER
Each 100ml contains Minoxidil 5g
PRODUCT DESCRIPTION
Clear colourless solution.
PHARMACODYNAMICS
Minoxidil stimulates hair growth in alopecia androgenetica males and
females when applied topically. The
mechanism by which minoxidil stimulates hair growth and reverses the
hair loss process is not fully established,
but possible mechanisms may include the following:
-
increasing the diameter of the hair shaft and stimulating of hair
follicles,
-
stimulating anagen (active) growth,
-
prolonging the anagen phase
-
stimulation of telogen phase (resting hair follicles) into anagen
phase (active growth)
-
enhancing microcirculation to hair follicles (as peripheral
vasodilator).
The Vascular Endothelial Growth Factor (VEGF) is stimulated by
minoxidil and VEGF is presumably responsible for
the increased capillary fenestration, indicative of a high metabolic
activity, observed during the anagen phase.
Hair growth can be expected approximately after 4 or more months of
application of use and is variable among
patients. Upon discontinuation of treatment with minoxidil, new hair
growth stops and pre-treatment appearance
may return within 3 – 4 months.
PHARMACOKINETICS
Following topical application, minoxidil is poorly absorbed from
normal intact skin, with an average of 1.7% (range
0.3 – 4.5%) of the total applied dose ultimately reaching the
systemic circulation. Three major factors that can
increase the absorption of minoxidil are increased of the dose
applied, increased of the dosing frequency, and
decreased of the barrier function of the stratum corneum.
Serum minoxidil level and systemic effects resulting from the
administration of minoxidil are governed by the
drug’s absorption rate through the skin. Minoxidil is not bound to
plasma protein and does not cross blood brain
barrier. Minoxidil and its metabolites are haemodialysable, and
excreted principally in the urine within 4 days.
INDICATION
RETEN FIVE SOLUTION 5G/10