দেশ: অস্ট্রেলিয়া
ভাষা: ইংরেজি
সূত্র: Department of Health (Therapeutic Goods Administration)
Nifedipine
Aspen Pharma Pty Ltd
Medicine Registered
APO-Nifedipine XR Tablets 1 APO-NIFEDIPINE XR _Contains the active ingredient, nifedipine_ _ _ _ _ CONSUMER MEDICINE INFORMATION _FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055 _ WHAT IS IN THIS LEAFLET READ THIS LEAFLET CAREFULLY BEFORE TAKING YOUR MEDICINE. This leaflet answers some common questions about APO-Nifedipine XR. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the last page. More recent information on this medicine may be available. ASK YOUR DOCTOR OR PHARMACIST: • if there is anything you do not understand in this leaflet, • if you are worried about taking your medicine, or • to obtain the most up-to-date information. You can also download the most up to date leaflet from www.apotex.com.au. All medicines have risks and benefits. Your doctor has weighed the risks of you using this medicine against the benefits they expect it will have for you. Pharmaceutical companies cannot give you medical advice or an individual diagnosis. Keep this leaflet with your medicine. You may want to read it again. WHAT THIS MEDICINE IS USED FOR The name of your medicine is APO- Nifedipine XR. It contains the active ingredient, nifedipine. It is used to treat hypertension (high blood pressure) or to prevent chronic stable angina, a type of angina. APO-Nifedipine XR is not used for the relief of a sudden attack of angina. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason. This medicine is available only with a doctor's prescription. _HOW IT WORKS _ Nife সম্পূর্ণ নথি পড়ুন
APO- NIFEDIPINE- Product Information Page 1 of 13 PRODUCT INFOMRATION APO-NIFEDIPINE XR TABLETS NAME OF THE MEDICINE Nifedipine. Chemical Name: dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate. Structural Formula: Molecular Formula: C 17 H 18 N 2 O 6 Molecular Weight: 346.3 CAS Registry Number: 21829-25-4 DESCRIPTION Nifedipine is a yellow, crystalline powder which is practically insoluble in water and sparingly soluble in absolute ethanol. It is sensitive to light. PHARMACOLOGY PHARMACOKINETICS Nifedipine is almost completely absorbed after oral administration. Plasma drug concentrations rise at a gradual, controlled rate exhibiting zero order absorption kinetics after nifedipine extended release tablet administration and reach a plateau at approximately six hours after the first dose. For subsequent doses, relatively constant plasma concentrations at this plateau are maintained with minimal fluctuations over the 24 hour dosing interval. At steady state, the bioavailability of nifedipine extended release tablets is 86% relative to an immediate release dosage form which has a systemic availability of 45 to 68%. Administration of nifedipine extended release tablets in the presence of food slightly alters the early rate of drug absorption, but does not influence the extent of drug bioavailability. Markedly reduced gastrointestinal retention times over prolonged periods (i.e. short bowel syndrome) may, however, influence the pharmacokinetic profile of the drug, which could result in lower plasma concentrations. The pharmacokinetics of nifedipine extended release tablets are linear over the dose range of 30 to 180 mg, in that plasma concentrations are proportional to dose administered. সম্পূর্ণ নথি পড়ুন