البلد: الولايات المتحدة
اللغة: الإنجليزية
المصدر: NLM (National Library of Medicine)
SEVOFLURANE (UNII: 38LVP0K73A) (SEVOFLURANE - UNII:38LVP0K73A)
MWI
SEVOFLURANE
SEVOFLURANE 1 mL in 1 mL
RESPIRATORY (INHALATION)
PRESCRIPTION
Sevoflurane is indicated for induction and maintenance of general anesthesia in dogs. Sevoflurane is contraindicated in dogs with a known sensitivity to sevoflurane or other halogenated agents.
Sevoflurane is packaged in amber colored bottles containing 250 mL sevoflurane, V1 510090.
New Animal Drug Application
SEVOFLURANE- SEVOFLURANE INHALANT MWI ---------- SEVOFLURANE SEVOFLURANE INHALATION ANESTHETIC FOR USE IN DOGS CAUTION: FEDERAL LAW RESTRICTS THIS DRUG TO USE BY OR ON THE ORDER OF A LICENSED VETERINARIAN. DESCRIPTION: Sevoflurane, a volatile liquid, is a halogenated general inhalation anesthetic drug. Its chemical name is fluoromethyl 2,2,2-trifluoro-l-(trifluoromethyl) ethyl ether, and its structural formula is: Sevoflurane Physical Constants are: Molecular Weight 200.05 Boiling Point at 760 mm Hg 58.6 °C Specific Gravity at 20°C 1.520 - 1.525 g/mL Vapor Pressure in mm Hg at 20 °C 157 at 25 °C 197 at 36 °C 317 Distribution Partition Coefficients at 37 °C: Blood/Gas 0.63 - 0.69 Water/Gas 0.36 Olive Oil/Gas 47 - 54 Brain/Gas 1.15 Mean Component/Gas Partition Coefficients at 25°C for Polymers Used Commonly in Medical Applications: Conductive rubber 14.0 Butyl rubber 7.7 Polyvinyl chloride 17.4 Polyethylene 1.3 Sevoflurane is nonflammable and nonexplosive as defined by the requirements of International Electrotechnical Commission 601-2-13. Sevoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Sevoflurane is nonpungent. It is miscible with ethanol, ether, chloroform and petroleum benzene, and it is slightly soluble in water. Sevoflurane is stable when stored under normal room lighting condition according to instructions. INDICATIONS: Sevoflurane is indicated for induction and maintenance of general anesthesia in dogs. DOSAGE AND ADMINISTRATION: INSPIRED CONCENTRATION: The delivered concentration of Sevoflurane should be known. Since the depth of anesthesia may be altered easily and rapidly, only vaporizers producing predictable percentage concentrations of sevoflurane should be used. Sevoflurane should be vaporized using a precision vaporizer specifically calibrated for sevoflurane. Sevoflurane contains no stabilizer. Nothing in the drug product alters calibration or operation of these vaporizers. The administration of general anesthesia must be individualized based اقرأ الوثيقة كاملة