XYLOCAINE- lidocaine hcl injection, solution

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

LIDOCAINE HYDROCHLORIDE ANHYDROUS (UNII: EC2CNF7XFP) (LIDOCAINE - UNII:98PI200987)

可用日期:

General Injectables & Vaccines, Inc

INN（国际名称）:

LIDOCAINE HYDROCHLORIDE ANHYDROUS

组成:

LIDOCAINE HYDROCHLORIDE ANHYDROUS 20 mg in 1 mL

给药途径:

INFILTRATION

处方类型:

PRESCRIPTION DRUG

疗效迹象:

Xylocaine (lidocaine HCl) Injections are indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks, when the accepted procedures for these techniques as described in standard textbooks are observed. Lidocaine HCl is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type.

產品總結:

All solutions should be stored at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light. All trademarks are the property of Fresenius Kabi USA, LLC. APP Fresenius Kabi USA, LLC Lake Zurich, IL 60047 451175D Revised: November 2014

授权状态:

New Drug Application

产品特点

XYLOCAINE- LIDOCAINE HCL INJECTION, SOLUTION
GENERAL INJECTABLES & VACCINES, INC
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XYLOCAINE 2% (LIDOCAINE HCL, INJECTION, USP) 20MG/ML 50ML MULTIPLE
DOSE VIAL
DESCRIPTION
Xylocaine (lidocaine HCl) Injections are sterile, nonpyrogenic,
aqueous solutions that
contain a local anesthetic agent with or without epinephrine and are
administered
parenterally by injection. See INDICATIONS AND USAGE section for
specific uses.
Xylocaine solutions contain lidocaine HCl, which is chemically
designated as acetamide, 2-
(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride and has the
molecular wt.
270.8. Lidocaine HCl (C14H22N2O • HCl) has the following structural
formula:
Epinephrine is (-) -3, 4-Dihydroxy-α-[(methylamino) methyl] benzyl
alcohol and has the
molecular wt. 183.21. Epinephrine (C9H13NO3) has the following
structural formula:
Dosage forms listed as Xylocaine-MPF indicate single dose solutions
that are Methyl
Paraben Free (MPF).
Xylocaine MPF is a sterile, nonpyrogenic, isotonic solution containing
sodium chloride.
Xylocaine in multiple dose vials: Each mL also contains 1 mg
methylparaben as antiseptic
preservative. The pH of these solutions is adjusted to approximately
6.5 (5.0 to 7.0) with
sodium hydroxide and/or hydrochloric acid.
Xylocaine MPF with Epinephrine is a sterile, nonpyrogenic, isotonic
solution containing
sodium chloride. Each mL contains lidocaine hydrochloride and
epinephrine, with 0.5 mg
sodium metabisulfite as an antioxidant and 0.2 mg citric acid as a
stabilizer.
Xylocaine with Epinephrine in multiple dose vials: Each mL also
contains 1 mg
methylparaben as antiseptic preservative. The pH of these solutions is
adjusted to
approximately 4.5 (3.3 to 5.5) with sodium hydroxide and/or
hydrochloric acid. Filled
under nitrogen.
CLINICAL PHARMACOLOGY
Mechanism of Action
Lidocaine HCl stabilizes the neuronal membrane by inhibiting the ionic
fluxes required for
the initiation and conduction of impulses thereby effecting local
anesthetic action.
Hemodynamics
Excessive blood levels may cau