资料单张
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
_ _
VIREST CREAM 5%
Aciclovir
1
WHAT IS IN THIS LEAFLET
1.
What Virest Cream 5% is used
for
2.
How Virest Cream 5% works
3.
Before you use Virest Cream
5%
4.
How to use Virest Cream 5%
5.
While you are using Virest
Cream 5%
6.
Side effects
7.
Storage and Disposal of
Virest Cream 5%
8.
Product description
9.
Manufacturer
and
Product Registration Holder
10.
Date of revision
WHAT VIREST CREAM 5% IS USED
FOR
Virest
Cream
5%
contains
a
medicine
called
aciclovir.
This
belongs
to
a
group
of
medicine
called antivirals. It works by killing
or stopping the growth of viruses.
Virest Cream 5% is used for the
treatment of herpes simplex viral
infections
of
the
skin
including
initial and recurrent genital herpes
and herpes labialis.
HOW VIREST CREAM 5% WORKS
Aciclovir is converted to aciclovir
monophosphate,
a
nucleotide,
by
the
viral
thymidine
kinases
of
herpes
simplex
virus
(HSV).
Aciclovir
monophosphate
is
converted
to
the
diphosphate
by
cellular guanylate kinase and to the
triphosphate
by
a
number
of
cellular
enzymes.
Aciclovir
triphosphate
interferes
with
HSV
DNA polymerase and inhibits viral
DNA replication. The triphosphate
can be incorporated into growing
chains
of
DNA
by
viral
DNA
polymerase,
resulting
in
termination
of
the
DNA
chain.
Aciclovir
is
therefore
selectively
converted to the active triphosphate
form by HSV-infected cells and it
is
much
less
toxic
to
normal
uninfected cells.
BEFORE YOU USE VIREST CREAM 5%
_ _
_- When you must not use it_
_ _
Do not take this medicine if you
are hypersensitive to
aciclovir
or
ganciclovir.
Do not take this medicine after the
expiry date printed on the pack or
if the packaging is damaged.
_Pregnancy and lactation_
_ _
Ask your doctor or pharmacist for
advice before using any medicine.
_-_
_ _
_Before you start use it_
_ _
Tell your doctor or pharmacist if:
•
if you are a woman with herpes
genitalis
_-_
_ _
_Taking other medicines_
_ _
Tell your doctor if you are taking
any other medicines, including any
that you buy without a
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