UNIMOL PARACETAMOL TABLET 500MG

国家: 马来西亚

语言: 英文

来源: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

有效成分:

Paracetamol

可用日期:

UNIMED SDN BHD

INN（国际名称）:

Paracetamol

每包单位数:

50tablet Tablets; 1 x 10tablet Tablets

厂商:

KCK PHARMACEUTICAL INDUSTRIES SDN. BHD.

产品特点

UNIMOL PARACETAMOL TABLET 500MG
Each tablet contains:
Paracetamol B.P. ……………. 500 mg
Preservatives:
Ethyl Paraben ……………….. 0.05% w/w
Propyl Paraben ……………… 0.05% w/w
PRODUCT DESCRIPTION:
White colour, circular biconvex tablet, with “_UNIMOL_” embossed
on one side.
PHARMACODYNAMICS:
Paracetamol is a centrally acting analgesic and antipyretic with
minimal anti-inflammatory properties.
Analgesic
The mechanism of analgesic action has not been fully determined.
Paracetamol may act predominantly
by inhibiting prostaglandin synthesis in the central nervous system
(specifically cyclooxygenase
(COX)-2) and, to a lesser extent, through a peripheral action by
blocking pain-impulse generation.
The peripheral action may also be due to inhibition of prostaglandin
synthesis or to inhibition of the
synthesis or actions of other substances that sensitize pain receptors
to mechanical or chemical
stimulation.
Antipyretic
Paracetamol
act
centrally
on
the
hypothalamic
heat-regulating
center
to
produce
peripheral
vasodilatation resulting in increase blood flow through the skin,
sweating and heat loss.
Paracetamol reduces fever by inhibiting the formulation and release of
prostaglandins in the CNS and
by inhibiting endogenous pyrogens at the hypothalamic thermoregulator
center.
PHARMACOKINETICS:
Following oral administration paracetamol is rapidly absorbed.
Paracetamol absorption takes place mainly in the small intestine and
therefore the rate of absorption is
depending on the rate of gastric emptying. It has been shown that
drugs which delay gastric emptying
also delay the absorption of paracetamol whereas metoclopramide (a
drug which increases the rate of
gastric emptying) accelerates absorption of the analgesic through the
total amount absorbed doses not
increase.
The presence of food in the stomach has also been reported to reduce
the rate of absorption of
paracetamol. Alterations in gastric pH have no appreciable effect on
paracetamol absorption.
During absorption, the amount of paracetamol whi