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SIGMAXIN- Consumer Medicine Information
Page 1 of 4
SIGMAXIN
digoxin
CONSUMER MEDICINE INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about
SIGMAXIN
. It does
not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking
SIGMAXIN
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again.
WHAT SIGMAXIN IS
USED FOR
SIGMAXIN
belongs to a group of
medicines known as
cardiac
glycosides.
They work by slowing
down the rate while increasing the
force of your heart when it beats.
It is used to treat certain heart
problems, such as:
CHRONIC HEART FAILURE
Heart failure is when your heart
can’t pump strongly enough to
supply blood needed through out
the whole body. It is not the same
as a heart attack and does not
mean that your heart stops.
CERTAIN TYPE OF IRREGULAR HEART
BEATS
Irregular heart rhythms caused by
an electrical problem in the upper
chamber of your heart. They cause
your heart to beat too fast or in an
uneven way.
Your doctor may have prescribed
this medicine for another reason.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY
SIGMAXIN
HAS BEEN PRESCRIBED
FOR YOU.
There is no evidence that
SIGMAXIN
is addictive.
BEFORE YOU TAKE IT
WHEN YOU MUST NOT TAKE IT
DO NOT TAKE
SIGMAXIN
IF YOU
HAVE AN ALLERGY TO:
digoxin or other cardiac
glycosides
any of the ingredients listed at
the end of th
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产品特点
SIGMAXIN- Product Information
Page 1 of 15
PRODUCT INFORMATION
NAME OF THE DRUG
SIGMAXIN TABLETS contain DIGOXIN 0.250 MG, Lactose, maize starch, hydrolyzed maize starch,
rice starch, magnesium stearate.
SIGMAXIN PG TABLETS contain DIGOXIN 0.0625 MG, Lactose, maize starch, hydrolyzed maize
starch, rice starch, magnesium stearate, povidone, colouring
(indigo carmine - CI73015).
DESCRIPTION
Digoxin has the molecular formula C
41
H
64
O
14
(_CAS_
– 20830 – 75 – 5) with a molecular weight of
781.0. It is practically insoluble in water and in ether and slightly soluble in alcohol. Digoxin is
obtained from the leaves of _Digitalis lanata_ and occurs as odourless, colourless or white crystals or
a white or almost white powder.
PHARMACOLOGY
MECHANISM OF ACTIONS:
Digoxin is a cardiac glycoside with
molecular haemodynamic, neurohumoral and
electrophysiological effects contributing to its efficacy in
heart failure.
Primary action of Digoxin is to reversibly inhibit the alpha
subunit of sodium-potassium
adenosine triphosphatase (ATPase). This result in
inhibitors of sodium-potassium exchange
allowing calcium to accumulate in cardiac myocytes
by augmenting calcium ion influx. This is
responsible for the positive inotropic effect of digoxin
or increase force of contraction. This
action is more pronounced in decompensated heart failure with
systolic dysfunction.
O
Me
OH
O
O
_R_
O
Me
HO
OH
2
O
O
H
HO
Me
H
HO
H
H
Me
H
H
R =
SIGMAXIN- Product Information
Page 2 of 15
Extracellular potassium promotes dephosphorylation
of the ATPase and decreases the
affinity of the enzyme for digoxin.
Digoxin
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