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SERC tablets
SCHEDULING STATUS:
S3
PROPRIETARY NAME
(and dosage form):
SERC tablets
COMPOSITION
Each Serc tablet contains
betahistine
dihydrochloride 4 mg.
PHARMACOLOGICAL CLASSIFICATION
A. 5.6 Histamine.
PHARMACOLOGICAL ACTION
Betahistine dihydrochloride is an analogue of histamine. Betahistine dihydrochloride is readily absorbed from the
gastrointestinal tract. It is converted to two metabolites and peak concentrations in blood of the two metabolites are
achieved within 3 to 5 hours. Most of a dose is excreted in the urine, in the form of the metabolites, in about 3 days.
The mechanism of action of betahistine is not known. Pharmacological testing in animals has shown that the blood
circulation in the striae vascularis of the inner ear improves, probably by means of a relaxation of the precapillary
sphincters of the microcirculation of the inner ear.
In pharmacological studies, betahistine was found to have weak H
1
receptor agonistic and considerable H
3
antagonistic
properties in the central nervous system and autonomic nervous system. Betahistine was also found to have a dose
dependent inhibiting effect on spike generation of neurons in lateral and medial vestibular nuclei. The importance of this
observation in the action against Ménière’s syndrome or vestibular vertigo, however, remains unclear.
INDICATIONS
Ménière’s syndrome.
CONTRA-INDICATIONS
Hypersensitivity to any of the ingredients.
Patients with active peptic ulcer.
Patients with phaeochromocytoma.
DOSAGE AND DIRECTIONS FOR USE
Initial dose:
Two to four tablets three times daily with meals.
Maintenance dose: Six to twelve tablets daily.
SIDE EFFECTS AND SPECIAL PRECAUTIONS
Gastro-intestinal disturbances, headache and skin rashes have been reported.
Special precautions
Serc tablets should be given with car
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