POTASSIUM CHLORIDE injection, solution, concentrate

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

POTASSIUM CHLORIDE (UNII: 660YQ98I10) (POTASSIUM CATION - UNII:295O53K152)

可用日期:

Fresenius Kabi USA, LLC

INN（国际名称）:

POTASSIUM CHLORIDE

组成:

POTASSIUM CATION 2 meq in 1 mL

给药途径:

INTRAVENOUS

处方类型:

PRESCRIPTION DRUG

疗效迹象:

Potassium Chloride for Injection Concentrate, USP is indicated in the treatment of potassium deficiency states when oral replacement is not feasible. Potassium Chloride for Injection Concentrate is contraindicated in diseases where high potassium levels may be encountered, and in patients with hyperkalemia, renal failure and in conditions in which potassium retention is present.

產品總結:

The following are packaged in plastic vials. These are Single Dose Vials, no preservative added, packaged 25 vials per tray.  Unused portion of vial should be discarded. This is a Multiple Dose Vial, preserved with 0.05% methylparaben and 0.005% propylparaben, packaged 25 vials per tray. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Use only if solution is clear, seal intact and undamaged. Vial stoppers do not contain natural rubber latex.

授权状态:

Abbreviated New Drug Application

产品特点

POTASSIUM CHLORIDE - POTASSIUM CHLORIDE INJECTION, SOLUTION,
CONCENTRATE
FRESENIUS KABI USA, LLC
----------
POTASSIUM CHLORIDE FOR INJECTION CONCENTRATE USP
Rx only
CONCENTRATE MUST BE
DILUTED BEFORE USE
_FOR INTRAVENOUS INFUSION ONLY_
_MUST BE DILUTED PRIOR TO INJECTION_
DESCRIPTION:
Potassium Chloride for Injection Concentrate, USP is a sterile,
nonpyrogenic
concentrated solution of Potassium Chloride, USP in Water for
Injection to be
administered by intravenous infusion only after dilution in a larger
volume of fluid.
Each mL of Potassium Chloride for Injection Concentrate contains 2 mEq
of K and
Cl_ _equivalent to 149 mg of potassium chloride and has an osmolarity
of 4000 mOsmol/L
(calc). A more concentrated Potassium Chloride for Injection
Concentrate is also
available. Each mL of this injection contains 3 mEq of K and Cl
equivalent to 224 mg of
potassium chloride and has an osmolarity of 6000 mOsmol/L(calc).
pH (4.0-8.0) may have been adjusted with hydrochloric acid and if
necessary, potassium
hydroxide.
Some packages are intended for multiple dose use and contain
preservatives (0.05%
methylparaben and 0.005% propylparaben). A summary of the available
products is
presented in the HOW SUPPLIED section.
Potassium Chloride for Injection Concentrate (appropriately diluted)
is a parenteral fluid
and electrolyte replenisher.
CLINICAL PHARMACOLOGY:
Potassium is the chief cation of body cells (160 mEq/L of
intracellular water) and is
concerned with the maintenance of body fluid composition and
electrolyte balance.
Potassium participates in carbohydrate utilization and protein
synthesis, and is critical in
the regulation of nerve conduction and muscle contraction,
particularly in the heart.
Chloride, the major extracellular anion, closely follows the
metabolism of sodium, and
changes in the acid-base balance of the body are reflected by changes
in the chloride
concentration.
Normally about 80 to 90% of the potassium intake is excreted in the
urine, the
remainder in the stools and to a small extent, in the perspirati