资料单张
PANTOCID 40 MG INJECTION
SCHEDULING STATUS:
S4
PROPRIETARY NAME
(and dosage form):
PANTOCID 40 MG INJECTION
Lyophilised Powder for Injection.
COMPOSITION
Each vial contains pantoprazole sodium equivalent to 40 mg
pantoprazole
.
PHARMACOLOGICAL CLASSIFICATION
A. 11.4.3 Medicines acting on the gastro-intestinal tract.
PHARMACOLOGICAL ACTION
Site and mechanism of action
Pantoprazole is a
proton pump inhibitor, i.e. it inhibits specifically and dose-proportionally H
+
, K
+
,-ATPase, the
enzyme which is responsible for gastric acid secretion in the parietal cells of the stomach.
Pantoprazole is a substituted benzimidazole which accumulates in the acidic compartment of the parietal cells after
absorption. In the parietal cell it is protonated and chemically re-arranged to the active inhibitor, a cyclic sulphenamide,
which binds to the H
+
, K
+
,-ATPase, thus inhibiting the proton pump and causing suppression of stimulated and basal
gastric acid secretion after single and multiple intravenous and oral pantoprazole dosing. Because pantoprazole acts
distal to the receptor level, it can influence gastric acid secretion irrespective of the nature of the stimulus.
Pantoprazole exerts its full effect in a strongly acidic environment (pH<3) and remains mostly inactive at higher pH
values, which explains its selectivity for the acid secreting parietal cells of the stomach. Therefore, the complete
pharmacological and therapeutic effect for pantoprazole can only be achieved in the acid-secreting parietal cells. By
means of a feedback mechanism this effect is diminished at the same rate as acid secretion is inhibited.
Effect on gastric acid secretion
Although pantoprazole has a half-life of approximately 1 hour, the antisecretory effect increases during repeated once
daily ad
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