MINOXIDIL tablet

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

MINOXIDIL (UNII: 5965120SH1) (MINOXIDIL - UNII:5965120SH1)

可用日期:

Cardinal Health

INN（国际名称）:

MINOXIDIL

组成:

MINOXIDIL 2.5 mg

处方类型:

PRESCRIPTION DRUG

授权状态:

Abbreviated New Drug Application

产品特点

MINOXIDIL- MINOXIDIL TABLET
CARDINAL HEALTH
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MINOXIDIL TABLETS, USP
WARNINGS
Minoxidil tablets contain the powerful antihypertensive agent,
minoxidil, which may produce
serious adverse effects. It can cause pericardial effusion,
occasionally progressing to tamponade,
and angina pectoris may be exacerbated. Minoxidil should be reserved
for hypertensive patients
who do not respond adequately to maximum therapeutic doses of a
diuretic and two other
antihypertensive agents.
In experimental animals, minoxidil caused several kinds of myocardial
lesions as well as other
adverse cardiac effects (see Cardiac Lesions in Animals).
Minoxidil must be administered under close supervision, usually
concomitantly with therapeutic
doses of a beta-adrenergic blocking agent to prevent tachycardia and
increased myocardial
workload. It must also usually be given with a diuretic, frequently
one acting in the ascending limb
of the loop of Henle, to prevent serious fluid accumulation. Patients
with malignant hypertension
and those already receiving guanethidine (see WARNINGS) should be
hospitalized when
minoxidil is first administered so that they can be monitored to avoid
too rapid, or large
orthostatic, decreases in blood pressure.
DESCRIPTION
Minoxidil tablets contain minoxidil, an antihypertensive peripheral
vasodilator. Minoxidil occurs as a
white to off-white, odorless, crystalline solid that is soluble in
water to the extent of approximately 2
mg/mL, is readily soluble in propylene glycol or ethanol, and is
almost insoluble in acetone, chloroform
or ethyl acetate. The chemical name for minoxidil is
2,4-pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide.
C H N 0 MW 209.25
Minoxidil tablets for oral administration contain either 2.5 mg or 10
mg of minoxidil. Inactive
ingredients include colloidal silicon dioxide, corn starch, lactose
anhydrous, magnesium stearate and
microcrystalline cellulose.
CLINICAL PHARMACOLOGY
1. GENERAL PHARMACOLOGIC PROPERTIES
Minoxidil is an orally effective direct acting peripheral vasodilator
that r