METOPROLOL SUCCINATE E/R- metoprolol succinate tablet, extended release

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

METOPROLOL SUCCINATE (UNII: TH25PD4CCB) (METOPROLOL - UNII:GEB06NHM23)

可用日期:

DirectRX

INN（国际名称）:

METOPROLOL SUCCINATE

组成:

METOPROLOL TARTRATE 50 mg

给药途径:

ORAL

处方类型:

PRESCRIPTION DRUG

疗效迹象:

- 1.1 Hypertension Metoprolol succinate extended-release tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including metoprolol. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). Numerous antihypertensive drugs, from a var

授权状态:

Abbreviated New Drug Application

产品特点

METOPROLOL SUCCINATE E/R- METOPROLOL SUCCINATE TABLET, EXTENDED
RELEASE
DIRECTRX
----------
METOPROLOL SUCCINATE
BOXED WARNING SECTION
WARNING: ISCHEMIC HEART DISEASE: Following abrupt cessation of therapy
with
certain beta-blocking agents, exacerbations of angina pectoris and, in
some cases, myocardial
infarction have occurred. When discontinuing chronically administered
metoprolol succinate
extended-release, particularly in patients with ischemic heart
disease, the dosage should be
gradually reduced over a period of 1 to 2 weeks and the patient should
be carefully monitored.
If angina markedly worsens or acute coronary insufficiency develops,
metoprolol succinate
extended-release administration should be reinstated promptly, at
least temporarily, and other
measures appropriate for the management of unstable angina should be
taken. Warn patients
against interruption or discontinuation of therapy without the
physician’s advice. Because
coronary artery disease is common and may be unrecognized, it may be
prudent not to
discontinue metoprolol succinate extended-release therapy abruptly
even in patients treated
only for hypertension (5.1).
INDICATIONS & USAGE SECTION
1.1 Hypertension
Metoprolol succinate extended-release tablets are indicated for the
treatment of hypertension, to
lower blood pressure. Lowering blood pressure lowers the risk of fatal
and non-fatal
cardiovascular events, primarily strokes and myocardial infarctions.
These benefits have been seen
in controlled trials of antihypertensive drugs from a wide variety of
pharmacologic classes
including metoprolol.
Control of high blood pressure should be part of comprehensive
cardiovascular risk management,
including, as appropriate, lipid control, diabetes management,
antithrombotic therapy, smoking
cessation, exercise, and limited sodium intake. Many patients will
require more than 1 drug to
achieve blood pressure goals. For specific advice on goals and
management, see published
guidelines, such as those of the National High Blood Pressure
Education Prog