LIOTHYRONINE SODIUM tablet

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

LIOTHYRONINE SODIUM (UNII: GCA9VV7D2N) (LIOTHYRONINE - UNII:06LU7C9H1V)

可用日期:

KAISER FOUNDATION HOSPITALS

INN（国际名称）:

LIOTHYRONINE SODIUM

组成:

LIOTHYRONINE 5 ug

处方类型:

PRESCRIPTION DRUG

授权状态:

Abbreviated New Drug Application

产品特点

LIOTHYRONINE SODIUM - LIOTHYRONINE SODIUM TABLET
KAISER FOUNDATION HOSPITALS
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DESCRIPTION
Thyroid hormone drugs are natural or synthetic preparations containing
tetraiodothyronine (T4,
levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or
both. T4 and T3 are produced
in the human thyroid gland by the iodination and coupling of the amino
acid tyrosine. T4 contains four
iodine atoms and is formed by the coupling of two molecules of
diiodotyrosine (DIT). T3 contains
three atoms of iodine and is formed by the coupling of one molecule of
DIT with one molecule of
monoiodotyrosine (MIT). Both hormones are stored in the thyroid
colloid as thyroglobulin.
Thyroid hormone preparations belong to two categories: (1) natural
hormonal preparations derived from
animal thyroid, and (2) synthetic preparations. Natural preparations
include desiccated thyroid and
thyroglobulin. Desiccated thyroid is derived from domesticated animals
that are used for food by man
(either beef or hog thyroid), and thyroglobulin is derived from
thyroid glands of the hog. The United
States Pharmacopeia (USP) has standardized the total iodine content of
natural preparations. Thyroid
USP contains not less than (NLT) 0.17 percent and not more than (NMT)
0.23 percent iodine, and
thyroglobulin contains not less than (NLT) 0.7 percent of organically
bound iodine. Iodine content is
only an indirect indicator of true hormonal biologic activity.
Liothyronine Sodium Tablets, USP contain liothyronine
(L-triiodothyronine or LT3), a synthetic form of
a natural thyroid hormone, and is available as the sodium salt.
The structural and empirical formulas and molecular weight of
liothyronine sodium are given below.
Twenty-five mcg of liothyronine is equivalent to approximately 1 grain
of desiccated thyroid or
thyroglobulin and 0.1 mg of L-thyroxine.
Each round, white Liothyronine Sodium Tablet, USP contains
liothyronine sodium equivalent to
liothyronine as follows: 5 mcg debossed 5 and 220; 25 mcg scored and
debossed 25 and 222; 50 mcg
scored a