国家: 新西兰
语言: 英文
来源: Medsafe (Medicines Safety Authority)
Lincomycin hydrochloride monohydrate 300 mg/mL;
Pharmacia Limited Company trading as Pharmacia
Lincomycin hydrochloride monohydrate 300 mg/mL
300 mg/mL
Solution for injection
Active: Lincomycin hydrochloride monohydrate 300 mg/mL Excipient: Benzyl alcohol Water for injection
Syringe, 2 mL
Prescription
Prescription
Pfizer Pharmaceuticals LLC
Package - Contents - Shelf Life: Syringe, - 2 mL - 60 months from date of manufacture stored at or below 25°C
1969-12-31
Version: pfdlinci11210 MoH Approved: Commercial/Non-Commercial Page 1 of 9 DATA SHEET LINCOCIN ® LINCOMYCIN INJECTION DESCRIPTION Non-proprietary name: lincomycin hydrochloride Chemical Name: Lincomycin hydrochloride consists mainly of the monohydrate of methyl 6,8-dideoxy-6-[(_2S,4R_)-1-methyl-4-propylpyrrolidine-2-carboxamido]-1-thio- D -erythro- - D - galacto-octopyranoside hydrochloride. CAS Number: 7179-49-9 The structure of lincomycin hydrochloride is: ACTIONS LINCOCIN (lincomycin hydrochloride) is the monohydrated salt of lincomycin, a substance produced by the growth of a member of the lincolnensis group of _Streptomyces lincolnensis _ _(fam. Streptomycetaceae)_. It is a white, or practically white, crystalline powder and is odourless or has a faint odour. Its solutions are acid and are dextrorotatory. LINCOCIN is freely soluble in water, soluble in dimethylformamide and very slightly soluble in acetone. LINCOCIN Injection is a clear, colourless or almost colourless solution, practically free from particles. MICROBIOLOGY _In vitro_ studies indicate that the following organisms are usually sensitive to concentrations achieved normally in the serum following recommended doses: _Staphylococcus aureus, _ _Staphylococcus epidermidis_, beta-haemolytic Streptococcus, _Streptococcus viridans, _ _Streptococcus pneumoniae, Clostridium tetani, Clostridium perfringens, Corynebacterium _ _diphtheriae._ Version: pfdlinci11210 MoH Approved: Commercial/Non-Commercial Page 2 of 9 NOTE: The drug is not active against most strains of _Enterococcus faecalis_, nor against _Neisseria _ _gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae_ or other gram-negative organisms or yeasts. Some strains of _Clostridium perfringens_ and strains of some less common human pathogens of Clostridia may be lincomycin-resistant. Depending on the sensitivity of the organism and concentration of the antibiot 阅读完整的文件