LEVAFEN- carprofen tablet

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

carprofen (UNII: FFL0D546HO) (carprofen - UNII:FFL0D546HO)

可用日期:

Patterson Veterinary

INN（国际名称）:

carprofen

组成:

carprofen 25 mg

给药途径:

ORAL

处方类型:

PRESCRIPTION

疗效迹象:

Carprofen is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. Carprofen should not be used in dogs exhibiting previous hypersensitivity to carprofen.

產品總結:

Levafen Caplets are scored, and contain 25 mg, 75 mg, or 100 mg of carprofen per caplet. Each caplet size is packaged in bottles containing 60 or 180 caplets.

授权状态:

Abbreviated New Animal Drug Application

产品特点

LEVAFEN- CARPROFEN TABLET
PATTERSON VETERINARY
----------
ANADA 200-498, Approved by FDA
LEVAFEN
CAPLETS
(CARPROFEN)
_NON-STEROIDAL ANTI-INFLAMMATORY DRUG_
FOR ORAL USE IN DOGS ONLY
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed veterinarian.
DESCRIPTION:
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the
propionic acid class that includes
ibuprofen, naproxen, and ketoprofen. Carprofen is the nonproprietary
designation for a substituted
carbazole, 6-chloro- -methyl-9H-carbazole-2-acetic acid. The empirical
formula is C
H ClNO and
the molecular weight 273.72.
The chemical structure of carprofen is:
Carprofen is a white, crystalline compound. It is freely soluble in
ethanol, but practically insoluble in
water at 25°C.
CLINICAL PHARMACOLOGY:
Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent
with characteristic analgesic and
antipyretic activity approximately equipotent to indomethacin in
animal models.
The mechanism of action of carprofen, like that of other NSAlDs, is
believed to be associated with the
inhibition of cyclooxygenase activity. Two unique cyclooxygenases have
been described in mammals.
The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins
necessary for normal
gastrointestinal and renal function. The inducible cyclooxygenase,
COX-2, generates prostaglandins
involved in inflammation. Inhibition of COX-l is thought to be
associated with gastrointestinal and renal
toxicity while inhibition of COX-2 provides anti-inflammatory
activity. The specificity of a particular
NSAID for COX-2 versus COX-1 may vary from species to species.
In an _in vitro_ study using canine
cell cultures, carprofen demonstrated selective inhibition of COX-2
versus COX-1.
Clinical relevance of these data has not been shown. Carprofen has
also been shown to inhibit the
release of several prostaglandins in two inflammatory cell systems:
rat polymorphonuclear leukocytes
(PMN) and human rheumatoid synovial cells, indicating inhibition of
acute (PMN system) an