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LENNON - STRONG CALCIFEROL TABLETS
SCHEDULING STATUS:
S3
PROPRIETARY NAME
(and dosage form):
LENNON - STRONG CALCIFEROL TABLETS
COMPOSITION:
Each tablet contains 1,25 mg of
Calciferol
(equivalent to: 50 000 IU of
Vitamin D
)
PHARMACOLOGICAL CLASSIFICATION:
A 22.1.4 Vitamins - Other.
PHARMACOLOGICAL ACTION:
Vitamin D is best characterised as a positive regulator of calcium homeostasis. Phosphate metabolism is affected by the
vitamin in a manner parallel to that of calcium. The mechanism by which Vitamin D acts to maintain normal
concentrations of calcium and phosphate in plasma are to facilitate their absorption by the small intestine, to interact
with parathyroid hormone to enhance their mobilization from bone, and to decrease their excretion by the kidney.
Vitamin D is essential for normal calcification of bone. Normal bone formation occurs when calcium and phosphate
concentrations in the plasma are adequate.
Vitamin D substances are well absorbed from the gastro intestinal tract. The presence of bile is essential for adequate
intestinal absorption.
Absorbed Vitamin D circulates in the blood in association with Vitamin D - binding protein.
The vitamin disappears from the plasma with a half life of 19 to 25 hours but is stored in fat depots for prolonged periods.
The primary route of excretion of Vitamin D is the bile.
Vitamin D and its metabolites undergo extensive enterohepatic recirculation.
INDICATIONS:
For the treatment of rickets, osteomalacia and hypoparathyroidism.
CONTRA-INDICATIONS:
Hypersensitivity to any of the ingredients.
Vitamin D should not be administered to patients with hypercalcaemia. It is advised that, if possible, women receiving
pharmacological doses of Vitamin D do not breast feed their infants as this may lead to the development of
hypercalcaemia
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