ISOFLURANE liquid

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

ISOFLURANE (UNII: CYS9AKD70P) (ISOFLURANE - UNII:CYS9AKD70P)

可用日期:

ASPEN VETERINARY RESOURCES LTD

给药途径:

RESPIRATORY (INHALATION)

处方类型:

PRESCRIPTION

疗效迹象:

Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs. Isoflurane, USP is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.

產品總結:

Isoflurane, USP, is packaged in 100 ml (NDC 46066-115-03) amber-colored bottle. Isoflurane, USP, is packaged in 250 ml (NDC 46066-115-04) amber-colored bottle. Storage: Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].

授权状态:

Abbreviated New Animal Drug Application

产品特点

ISOFLURANE - ISOFLURANE LIQUID
ASPEN VETERINARY RESOURCES LTD
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ISOFLURANE, USP INHALATION ANESTHETIC , VET [PIVETAL]
SPL UNCLASSIFIED SECTION
ISOFLURANE, USP
INHALATION ANESTHETIC
Nonflammable, nonexplosive.
For Veterinary Use in Horses and Dogs.
WARNING
Not for use in horses intended for food.
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
Operating rooms should be provided with adequate ventilation to
prevent the
accumulation of anesthetic vapors.
DESCRIPTION
Isoflurane, USP is a nonflammable, nonexplosive general inhalation
anesthetic agent. Its
chemical name is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether,
and its structural
formula is:
Each mL contains 99.9% isoflurane.
Some physical constants are:
Molecular weight
184.5
Boiling point at 760 mm Hg
48.5° C (uncorr.)
Refractive index _n _20
D
1.2990 to 1.3005D
Specific gravity 25°/25° C
1.496
Vapor pressure in mm Hg**
20° C
238
25° C
295
30° C
367
35° C
450
**Equation for vapor pressure calculation:
log10Pvap= A + B/T where: A = 8.056
B = -1664.58
T = °C + 273.16 (Kelvin)
Partition coefficients at 37° C:
Water/gas
0.61
Blood/gas
1.43
Oil/gas
90.8
Partition coefficients at 25° C - rubber and plastic
Conductive rubber/gas
62.0
Butyl rubber/gas
75.0
Polyvinyl chloride/gas
110.0
Polyethylene/gas
~2.0
Polyurethane/gas
~1.4
Polyolefin/gas
~1.1
Butyl acetate/gas
~2.5
Purity by gas chromatography
>99.9%
Lower limit of flammability in oxygen or
nitrous oxide at 9 joules/sec. and 23° C
None
Lower limit of flammability in oxygen or nitrous oxide at
900 joules/sec. and 23° C
Greater than useful concentration in anesthesia.
MAC (Minimum Alveolar Concentration) is 1.31% in horses and 1.28% in
dogs.
Isoflurane is a clear, colorless, stable liquid containing no
additives or chemical
stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor.
Samples stored in
indirect sunlight in clear, colorless glass for five years, as well as
samples directly
exposed for 30 hours to a 2 amp, 115 volt, 60 cyc