HYDROCORTISONE ACETATE PRAMOXINE HCL

国家: 美国

语言: 英文

来源: NLM (National Library of Medicine)

有效成分:

HYDROCORTISONE ACETATE (UNII: 3X7931PO74) (HYDROCORTISONE - UNII:WI4X0X7BPJ)

可用日期:

Acella Pharmaceuticals, LLC

INN（国际名称）:

HYDROCORTISONE ACETATE

组成:

HYDROCORTISONE ACETATE 25 mg in 1 g

处方类型:

PRESCRIPTION DRUG

授权状态:

unapproved drug other

产品特点

HYDROCORTISONE ACETATE PRAMOXINE HCL- HYDROCORTISONE ACETATE PRAMOXINE
HCL
ACELLA PHARMACEUTICALS, LLC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
----------
HYDROCORTISONE ACETATE 2.5%-PRAMOXINE HCL 1% CREAM KIT
RX ONLY
DESCRIPTION:
Hydrocortisone Acetate 2.5%-Pramoxine HCl 1% Cream is a topical
preparation containing
Hydrocortisone Acetate 2.5% w/w and Pramoxine HCl 1% w/w in a
hydrophilic base containing
purified water, cetostearyl alcohol, mineral oil, white petrolatum,
propylparaben, triethanolamine laurel
sulfate, citric acid, sodium citrate, isopropyl palmitate, stearic
acid, lanolin alcohol, methyl paraben,
potassium sorbate, sorbic acid, PEG-40 stearate and ceresin wax.
Topical corticosteroids are anti-
inflammatory and anti-puritic agents. The structural formula, the
chemical name, molecular formula and
molecular weight for active ingredients are presented below.
CLINICAL PHARMACOLOGY:
Topical corticosteroids share anti-inflammatory, anti-pruritic and
vasoconstrictive actions.
The mechanism of anti-inflammatory activity of topical corticosteroids
is unclear. Various laboratory
methods, including vasoconstrictor assays, are used to compare and
predict potencies and/or clinical
efficacies of the topical corticosteroids. There is some evidence to
suggest that a recognizable
correlation exists between vasoconstrictor potency and therapeutic
efficacy in man.
Pramoxine hydrochloride is a topical anesthetic agent which provides
temporary relief from itching and
Pramoxine hydrochloride is a topical anesthetic agent which provides
temporary relief from itching and
pain. It acts by stabilizing the neuronal membrane of nerve endings
with which it comes into contact.
PHARMACOKINETICS :
The extent of percutaneous absorption of topical corticosteroids is
determined by many factors
including the vehicle, the integrity of the epidermal barrier and the
use of occlusive dressings.